3-BROMO-1H-PYRROLE

Base Information

• Chemical Name: 3-BROMO-1H-PYRROLE
• CAS No.: 87630-40-8
• Molecular Formula: C4H4BrN
• Molecular Weight: 145.986
• Hs Code.: 2933990090
• Mol file: 87630-40-8.mol

Synonyms:3-Bromopyrrole;

Chemical Property of 3-BROMO-1H-PYRROLE

Chemical Property:

• Vapor Pressure: 0.273mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 210.837 °C at 760 mmHg
• PKA: 15.33±0.50(Predicted)
• Flash Point: 81.312 °C
• PSA: 15.79000
• Density: 1.739 g/cm³
• LogP: 1.77720

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-1H-pyrrole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-1H-PYRROLE

There total 4 articles about 3-BROMO-1H-PYRROLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-(p-toluenesulfonyl)-2,4-bis(trimethylsilyl)-3-bromo-1H-pyrrole → 3-bromo-1H-pyrrole (87630-40-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 66 ℃; for 2h;

DOI:10.1021/jo9915224

Reference yield: 65.0%

3-bromo-1-triisopropylsilanyl-1H-pyrrole (87630-36-2) → 3-bromo-1H-pyrrole (87630-40-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.0833333h; Ambient temperature;

DOI:10.1021/jo00313a019 DOI:10.1016/S0040-4039(00)86011-6

Reference yield:

tetrabutyl ammonium fluoride (429-41-4) + 3-bromo-1-triisopropylsilanyl-1H-pyrrole (87630-36-2) → 3-bromo-1H-pyrrole (87630-40-8)

Guidance literature:

In tetrahydrofuran; diethyl ether; water;

upstream raw materials:

3-bromo-1-triisopropylsilanyl-1H-pyrrole

tetrabutyl ammonium fluoride

Downstream raw materials:

3-bromo-1H-pyrrol-1-amine

N-nosyl-3-bromo-pyrrole

C₂₃H₂₀N₂O₃

1-benzyl-3-bromo-1H-pyrrole

Refernces

• 1、 Bedell, T. Aaron,Du Bois, J.,Merit, Jeffrey E.,Tang, Doris T. Y.. "Silylpyrrole Oxidation En Route to Saxitoxin Congeners including 11-Saxitoxinethanoic Acid". . p. 17790 - 17803. Retrieved 2021/12/17.
• 2、 -. "S1P3 ANTAGONISTS". Paragraph 0433-0434. . Retrieved 2016/10/31.