N-METHYL-L-PHENYLALANINE HYDROCHLORIDE

Base Information

• Chemical Name: N-METHYL-L-PHENYLALANINE HYDROCHLORIDE
• CAS No.: 66866-67-9
• Molecular Formula: C10H13 N O2 . Cl H
• Molecular Weight: 215.68
• Mol file: 66866-67-9.mol

Synonyms:N-Methylphenylalaninehydrochloride

Chemical Property of N-METHYL-L-PHENYLALANINE HYDROCHLORIDE

Chemical Property:

• Melting Point: 191-195 °C
• PSA: 49.33000
• LogP: 2.09460

Purity/Quality:

98%Min ^*data from raw suppliers

(s)-2-(Methylamino)-3-phenylpropanoicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-METHYL-L-PHENYLALANINE HYDROCHLORIDE

There total 17 articles about N-METHYL-L-PHENYLALANINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + Boc-N-Me-Phe-OH (37553-65-4) → N-methyl-L-phenylalanine hydrochloride (66866-67-9,1956434-77-7)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2013.07.044

Reference yield:

micropeptin MZ771 (1207348-80-8) → l-glutamic acid hydrochloride (138-15-8) + L-arginine hydrochloride (1119-34-2) + N-methyl-L-phenylalanine hydrochloride (66866-67-9,1956434-77-7) + L-isoleucine hydrochloride (17694-98-3) + L-threonine methyl ester hydrochloride (60143-52-4,71264-40-9,82650-07-5,97347-46-1,100157-61-7)

Guidance literature:

micropeptin MZ₇₇₁; With Jones reagent; In acetone; at 0 ℃; for 0.166667h;

With hydrogenchloride; water; at 110 ℃; for 16h; Sealed glass bomb;

DOI:10.1021/np900546u

Reference yield:

micropeptin MZ845 (914606-75-0) → D-glyceric acid (473-81-4,600-19-1,6000-40-4,28305-26-2,118916-26-0) + l-glutamic acid hydrochloride (138-15-8) + L-arginine hydrochloride (1119-34-2) + N-methyl-L-phenylalanine hydrochloride (66866-67-9,1956434-77-7) + L-isoleucine hydrochloride (17694-98-3) + L-threonine methyl ester hydrochloride (60143-52-4,71264-40-9,82650-07-5,97347-46-1,100157-61-7)

Guidance literature:

micropeptin MZ₈₄₅; With Jones reagent; In acetone; at 0 ℃; for 0.166667h;

With hydrogenchloride; water; at 110 ℃; for 16h; Sealed glass bomb;

DOI:10.1021/np900546u

upstream raw materials:

micropeptin MZ₈₄₅

micropeptin MZ₈₅₉

micropeptin MZ₉₃₉A

micropeptin MZ₉₂₅

Downstream raw materials:

N-methyl-L-phenylalanine methyl ester

-N-methyl-L-phenylalanin-methylester

(S)-2-[(3-Amino-propionyl)-methyl-amino]-3-phenyl-propionic acid methyl ester

{2-[((S)-1-Hydrazinocarbonyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-carbamic acid benzyl ester

Refernces

• 1、 Molinski, Tadeusz F.,Reynolds, Kirk A.,Morinaka, Brandon I.. "Symplocin A, a linear peptide from the bahamian cyanobacterium symploca sp. configurational analysis of N, N -dimethylamino acids by chiral-phase HPLC of naphthacyl esters". . p. 425 - 431. Retrieved 2012/07/13.