2-FLUORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL

Base Information

• Chemical Name: 2-FLUORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL
• CAS No.: 152211-15-9
• Molecular Formula: C8H6F4O
• Molecular Weight: 194.129
• Hs Code.: 2906299090
• Mol file: 152211-15-9.mol

Synonyms:2-Fluoro-6-(trifluoromethyl)benzenemethanol;2-Fluoro-6-(trifluoromethyl)benzyl alcohol;

Chemical Property of 2-FLUORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL

Chemical Property:

• Appearance/Colour: low-melting solid
• Vapor Pressure: 0.462mmHg at 25°C
• Refractive Index: n20/D 1.456(lit.)
• Boiling Point: 184.872 °C at 760 mmHg
• Flash Point: 65.609 °C
• PSA: 20.23000
• Density: 1.377 g/cm³
• LogP: 2.33680
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-6-(trifluoromethyl)benzyl alcohol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-FLUORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL

There total 3 articles about 2-FLUORO-6-(TRIFLUOROMETHYL)BENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-fluoro-6-(trifluoromethyl)benzoic acid (32890-94-1) → (2-fluoro-6-(trifluoromethyl)phenyl)methanol (152211-15-9)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 70.0%

(2-fluoro-6-(trifluoromethyl) phenyl)methanamine (239087-06-0) → (2-fluoro-6-(trifluoromethyl)phenyl)methanol (152211-15-9)

Guidance literature:

(2-fluoro-6-(trifluoromethyl) phenyl)methanamine; With hydrogenchloride; In 1,4-dioxane; water; pH=3;

With sodium nitrite; In 1,4-dioxane; water; for 6h; Reflux;

With water; sodium hydrogencarbonate; In dichloromethane; Solvent; pH-value;

Reference yield:

3-fluoro-trifluoromethylbenzene (401-80-9) → (2-fluoro-6-(trifluoromethyl)phenyl)methanol (152211-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran / 5 h / -78 - -60 °C / Inert atmosphere

2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran;

upstream raw materials:

(2-fluoro-6-(trifluoromethyl) phenyl)methanamine

2-fluoro-6-(trifluoromethyl)benzoic acid

3-fluoro-trifluoromethylbenzene

Downstream raw materials:

1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione

Refernces

• 1、 -. "Method for synthesizing Elagolix midbody polysubstituted pyrimidine derivate through two-step method". Page/Page column 6-10. . Retrieved 2019/06/11.