(R)-2-Amino-5-phenylpentanoic acid

Base Information

• Chemical Name: (R)-2-Amino-5-phenylpentanoic acid
• CAS No.: 36061-08-2
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Hs Code.: 2922499990
• European Community (EC) Number: 848-211-4
• Nikkaji Number: J1.605.661H
• Mol file: 36061-08-2.mol

Synonyms:(R)-2-Amino-5-phenylpentanoic acid;36061-08-2;(2R)-2-amino-5-phenylpentanoic acid;(R)-2-Amino-5-phenyl-pentanoic acid;2046-19-7;D-2-Amino-5-phenylpentanoic acid;(R)-2-Amino-5-phenylpentanoicacid;r-2-Amino-5-phenyl-pentanoic acid;(2R)-2-amino-5-phenyl-pentanoic acid;Benzenepentanoic acid, a-amino-, (R)-;SCHEMBL2130589;H-D-Phe{#(CH2)2}-OH;XOQZTHUXZWQXOK-SNVBAGLBSA-N;2(r)-amino-5-phenyl-pentanoic acid;2-(R)-Amino-5-phenylpentanoic acid;MFCD03844654;AKOS006343927;AC-9944;PS-12532;CS-0005262;W15607;A874454

Chemical Property of (R)-2-Amino-5-phenylpentanoic acid

Chemical Property:

• Vapor Pressure: 2.69E-06mmHg at 25°C
• Refractive Index: 1.555
• Boiling Point: 375.2 °C at 760 mmHg
• Flash Point: 180.7 °C
• PSA: 63.32000
• Density: 1.133g/cm³
• LogP: 2.12150
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 193.110278721
• Heavy Atom Count: 14
• Complexity: 176

Purity/Quality:

99% ^*data from raw suppliers

(R)-2-Amino-5-phenyl-pentanoicacid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCCC(C(=O)O)N
• Isomeric SMILES: C1=CC=C(C=C1)CCC[C@H](C(=O)O)N

Technology Process of (R)-2-Amino-5-phenylpentanoic acid

There total 4 articles about (R)-2-Amino-5-phenylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C2HF3O2*C12H17NO2 → (2R)-2-amino-5-phenylpentanoic acid (36061-08-2,2046-19-7)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃; for 6h; optical yield given as %ee;

DOI:10.3987/COM-08-S(D)30

Reference yield: 89.0%

→ (2R)-2-amino-5-phenylpentanoic acid (36061-08-2,2046-19-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; at 25 ℃; for 2h;

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 1h;

Reference yield: 47.29%

DL-N-acetyl-2-amino-5-phenylpentanoic acid (108019-30-3,5440-44-8) → (2R)-2-amino-5-phenylpentanoic acid (36061-08-2,2046-19-7)

Guidance literature:

With hydrogenchloride; potassium hydroxide; water; N-acyl-D-amino acid amidohydrolase; zinc(II) chloride; at 40 ℃; for 12h; pH=8.0;

upstream raw materials:

DL-N-acetyl-2-amino-5-phenylpentanoic acid

Cinnamyl bromide

Downstream raw materials:

3-MeOOC-Bzls-d-Ppg-OH

(R)-2-benzylsulfonylamino-5-phenylpentanoic acid

(R)-2-(2-tert-butoxycarbonylamino-2-methyl-propionylamino)-5-phenyl-pentanoic acid

Refernces

• 1、 Murai, Yuta,Hatanaka, Yasumaru,Kanaoka, Yuichi,Hashimoto, Makoto. "Effective synthesis of optically active 3-phenyl-3-(3-trifluoromethyl) diazirinyl bishomophenylalanine derivatives". body text. p. 359 - 364. Retrieved 2009/12/03.
• 2、 -. "Treatment of insulin resistance with growth hormone secretagogues". . . Retrieved 2008/06/13.