C₁₅H₂₁N₃O₄

Base Information

• Chemical Name: C₁₅H₂₁N₃O₄
• CAS No.: 1082937-60-7
• Molecular Formula: C₁₅H₂₁N₃O₄
• Molecular Weight: 307.349
• Mol file: 1082937-60-7.mol

Synonyms:C₁₅H₂₁N₃O₄

Chemical Property of C₁₅H₂₁N₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₂₁N₃O₄

There total 6 articles about C₁₅H₂₁N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C23H23N3O6 (1082937-58-3) → C15H21N3O4 (1082937-60-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

Reference yield:

tert-butyl N-(4-nitrophenyl)carbamate (18437-63-3) → C15H21N3O4 (1082937-60-7)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h

2: isopropyl alcohol / 16 h / Reflux

3: dmap / tetrahydrofuran / 16 h / Reflux

4: hydrazine / ethanol / 3 h / Reflux

With dmap; hydrogen; hydrazine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate; isopropyl alcohol;

Reference yield:

4-nitro-aniline (100-01-6,104810-17-5) → C15H21N3O4 (1082937-60-7)

Guidance literature:

Multi-step reaction with 6 steps

1: dmap / acetonitrile / 16 h / Reflux

2: potassium carbonate / methanol / 16 h / Reflux

3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h

4: isopropyl alcohol / 16 h / Reflux

5: dmap / tetrahydrofuran / 16 h / Reflux

6: hydrazine / ethanol / 3 h / Reflux

With dmap; hydrogen; potassium carbonate; hydrazine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; ethyl acetate; isopropyl alcohol; acetonitrile;

upstream raw materials:

C₂₃H₂₃N₃O₆

N-(tert-butoxycarbonyl)-1,4-phenylenediamine

4-nitro-aniline

tert-butyl N-(4-nitrophenyl)carbamate

Downstream raw materials:

C₂₀H₂₂ClN₃O₅S

N-{[(5S)-3-(4-aminophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}-5-chloro-2-thiophenecarboxamide

C₂₂H₂₇ClN₄O₅S

5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]-triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide

Refernces

• 1、 -. "FXA INHIBITORS WITH CYCLIC AMIDOXIME OR CYCLIC AMIDRAZONE AS P4 SUBUNIT, PROCESSES FOR THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS AND DERIVATIVES THEREOF". Page/Page column 16. . Retrieved 2011/05/16.
• 2、 -. "FXA INHIBITORS WITH CYCLIC AMIDINES AS P4 SUBUNIT, PROCESSES FOR THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS AND DERIVATIVES THEREOF". Page/Page column 35; 38. . Retrieved 2009/01/20.