7-Bromo-4-chromanone

Base Information

• Chemical Name: 7-Bromo-4-chromanone
• CAS No.: 18442-22-3
• Molecular Formula: C9H7BrO2
• Molecular Weight: 227.057
• Hs Code.: 2932999099
• Mol file: 18442-22-3.mol

Synonyms:7-Bromo-4-chromanone;

Chemical Property of 7-Bromo-4-chromanone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.599
• Boiling Point: 336.585 °C at 760 mmHg
• Flash Point: 157.361 °C
• PSA: 26.30000
• Density: 1.622 g/cm³
• LogP: 2.41430
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

7-Bromochroman-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used as a?intermediate for??R & D.

Technology Process of 7-Bromo-4-chromanone

There total 16 articles about 7-Bromo-4-chromanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-(3-bromophenoxy)propionic acid (18386-03-3) → 7-Bromo-2,3-dihydro-4H-chromen-4-one (18442-22-3)

Guidance literature:

With acid activated montmorillonite K-10; In toluene; for 0.5h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2021.153372

Reference yield: 78.0%

7-bromo-4H-benzopyran-4-one (168759-60-2) → 7-Bromo-2,3-dihydro-4H-chromen-4-one (18442-22-3)

Guidance literature:

7-bromo-4H-benzopyran-4-one; With diisobutylaluminium hydride; In tetrahydrofuran; n-heptane; at -78 ℃; for 0.5h;

With water; In tetrahydrofuran; n-heptane; at 20 ℃;

Reference yield: 74.0%

2,3-dihydro-4H-1-benzopyran-4-one (491-37-2) → 7-Bromo-2,3-dihydro-4H-chromen-4-one (18442-22-3)

Guidance literature:

2,3-dihydro-4H-1-benzopyran-4-one; aluminum (III) chloride; In dichloromethane; for 0.283333h;

With bromine; at 20 ℃; for 1h;

upstream raw materials:

C₉H₆BrClO

3-(3-bromophenoxy)propionic acid

7-bromo-4H-benzopyran-4-one

2,3-dihydro-4H-1-benzopyran-4-one

Downstream raw materials:

7-bromo-3-amino-chroman-4-one hydrochloride

(E,Z)-7-bromochroman-4-one O-tosyl oxime

tert-butyl [(7-phenyl-2H-chromen-4-yl)methyl]carbamate

1-(7-phenyl-3,4-dihydro-2H-chromen-4-yl)methanamine

Refernces

• 1、 -. "HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF". . . Retrieved 2021/02/25.
• 2、 -. "CHROMANE-SUBSTITUED TETRACYCLIC COMPOUNDS AND USES THEREOF FOR TREATMENT OF VIRAL DISEASES". Page/Page column 39; 40. . Retrieved 2018/03/09.