6-Iodo-2-Tetralone

Base Information

• Chemical Name: 6-Iodo-2-Tetralone
• CAS No.: 239783-48-3
• Molecular Formula: C₁₀H₉IO
• Molecular Weight: 272.085
• Mol file: 239783-48-3.mol

Synonyms:6-Iodo-2-tetralone;

Chemical Property of 6-Iodo-2-Tetralone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.644
• Boiling Point: 340.498 °C at 760 mmHg
• Flash Point: 159.728 °C
• PSA: 17.07000
• Density: 1.757 g/cm³
• LogP: 2.34900

Purity/Quality:

99% ^*data from raw suppliers

6-IODO-2-TETRALONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Iodo-2-Tetralone

There total 4 articles about 6-Iodo-2-Tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

ethene (74-85-1) + 4-Iodobenzeneacetyl chloride (37051-38-0) → 6-iodo-2-tetralone (239783-48-3)

Guidance literature:

With aluminium trichloride; In dichloromethane; at -15 ℃; for 1.5h;

DOI:10.1139/v99-006

Reference yield:

sodium; 6-iodo-3,4-dihydro-naphthalen-2-olate → 6-iodo-2-tetralone (239783-48-3)

Guidance literature:

With acetate buffer; In water; at 25 ℃; Rate constant;

DOI:10.1021/ja990070+

Reference yield:

(4-iodophenyl)acetic acid (1798-06-7) → 6-iodo-2-tetralone (239783-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂

2: 37 percent / AlCl₃ / CH₂Cl₂ / 1.5 h / -15 °C

With aluminium trichloride; thionyl chloride; In dichloromethane; 1: Chlorination / 2: Cycloaddition;

DOI:10.1139/v99-006

upstream raw materials:

ethene

4-Iodobenzeneacetyl chloride

(4-iodophenyl)acetic acid

Refernces

• 1、 Yao,Pollack. "Electronic effects on enol acidity and keto-enol equilibrium constants for ring-substituted 2-tetralones". . p. 634 - 638. Retrieved 2007/10/03.