7-Iodo-1-indanone

Base Information

• Chemical Name: 7-Iodo-1-indanone
• CAS No.: 628732-02-5
• Molecular Formula: C₉H₇IO
• Molecular Weight: 258.058
• Mol file: 628732-02-5.mol

Synonyms:7-Iodoindan-1-one;

Chemical Property of 7-Iodo-1-indanone

Chemical Property:

• Vapor Pressure: 0.000204mmHg at 25°C
• Refractive Index: 1.674
• Boiling Point: 327.3 ºC at 760 mmHg
• Flash Point: 151.7 ºC
• PSA: 17.07000
• Density: 1.882
• LogP: 2.42010
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Dihydro-7-iodoinden-1-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Iodo-1-indanone

There total 5 articles about 7-Iodo-1-indanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

7-amino-2,3-dihydro-1H-inden-1-one (628732-03-6) → 4-iodo-2,3-dihydro-1H-inden-1-one + 4,7-diiodo-1-indanone + 7-iodoindan-1-one (628732-02-5)

Guidance literature:

With copper(l) iodide; tert.-butylnitrite; diiodomethane; iodine; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2020.152427

Reference yield: 43.0%

7-amino-2,3-dihydro-1H-inden-1-one (628732-03-6) → 7-iodoindan-1-one (628732-02-5)

Guidance literature:

7-amino-2,3-dihydro-1H-inden-1-one; With hydrogenchloride; sodium nitrite; In water; acetic acid; at 0 ℃; for 0.0833333h;

With potassium iodide; In water; acetic acid; at 60 ℃; for 1h;

DOI:10.1021/jo035289s

Reference yield:

4-aminoindan (32202-61-2) → 7-iodoindan-1-one (628732-02-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 17 g / ethanol / 16 h / 20 °C

2.1: 14 g / potassium permanganate; MgSO₄ / acetone; H₂O / 16 h / 20 °C

3.1: 91 percent / aq. HCl / 3 h / 90 °C

4.1: HCl; NaNO₂ / H₂O; acetic acid / 0.08 h / 0 °C

4.2: 43 percent / KI / H₂O; acetic acid / 1 h / 60 °C

With hydrogenchloride; potassium permanganate; magnesium sulfate; sodium nitrite; In ethanol; water; acetic acid; acetone;

DOI:10.1021/jo035289s

upstream raw materials:

7-amino-2,3-dihydro-1H-inden-1-one

N-(3-oxo-2,3-dihydro-1H-inden-4-yl)acetamide

4-aminoindan

N-(2,3-dihydro-1H-inden-4-yl)acetamide

Refernces

• 1、 -. "4-(2-Methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihydro-imidazole-2-thione as specific alpha2B agonist and methods of using the same". . . Retrieved 2008/06/13.
• 2、 Nguyen, Phong,Corpuz, Evelyn,Heidelbaugh, Todd M.,Chow, Ken,Garst, Michael E.. "A Convenient Synthesis of 7-Halo-1-indanones and 8-Halo-1-tetralones". . p. 10195 - 10198. Retrieved 2007/10/03.