(2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid

Base Information

• Chemical Name: (2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid
• CAS No.: 1033772-60-9
• Molecular Formula: C₂₄H₂₃N₅O₃S
• Molecular Weight: 461.544
• Mol file: 1033772-60-9.mol

Synonyms:(2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid

Chemical Property of (2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid

There total 2 articles about (2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(1S)-N-(1-hydroxymethyl-2-methyl-propyl)-N'-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-thiophene-2-carboxamide (1033772-58-5) → (2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid (1033772-60-9)

Guidance literature:

(1S)-N-(1-hydroxymethyl-2-methyl-propyl)-N'-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-thiophene-2-carboxamide; With sodium hydroxide; potassium permanganate; 18-crown-6 ether; In dichloromethane; water; at 20 ℃; for 12h;

With sodium hydroxide; In dichloromethane; water; Alkaline conditions;

With hydrogenchloride; In water; pH=2; Product distribution / selectivity;

Reference yield: 72.0%

(4S)-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4-isopropyl-2-(2-thienyl)-1,3-oxazolidine (1033772-59-6) → (2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid (1033772-60-9)

Guidance literature:

(4S)-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4-isopropyl-2-(2-thienyl)-1,3-oxazolidine; With sodium hypochlorite; potassium carbonate; potassium bromide; In water; acetonitrile; at 0 - 20 ℃; for 1.25h;

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In water; acetonitrile;

With hydrogenchloride; sodium hydroxide; tartaric acid; more than 3 stages; Product distribution / selectivity;

Reference yield: 92.0%

(2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid (1033772-60-9) → N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine (137862-53-4,137862-87-4)

Guidance literature:

With sodium azide; dichloro[(-)-sparteine-N,N']copper(II); In ethyl acetate; at 70 - 80 ℃; for 4h; Concentration; Reagent/catalyst; Large scale;

upstream raw materials:

(1S)-N-(1-hydroxymethyl-2-methyl-propyl)-N'-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-thiophene-2-carboxamide

(4S)-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4-isopropyl-2-(2-thienyl)-1,3-oxazolidine

Downstream raw materials:

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

Refernces