6-Methoxy-3(2H)-benzofuranone

Base Information

• Chemical Name: 6-Methoxy-3(2H)-benzofuranone
• CAS No.: 15832-09-4
• Molecular Formula: C9H8O3
• Molecular Weight: 164.161
• Hs Code.: 2932999099
• Mol file: 15832-09-4.mol

Synonyms:6-Methoxy-3(2H)-benzofuranone;6-Methoxybenzofuran-3(2H)-one;6-Methoxycoumaran-3-one;6-Methoxycoumaranone;

Chemical Property of 6-Methoxy-3(2H)-benzofuranone

Chemical Property:

• Vapor Pressure: 0.0114mmHg at 25°C
• Melting Point: 119-120 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.557
• Boiling Point: 313 °C at 760 mmHg
• Flash Point: 134.1 °C
• PSA: 35.53000
• Density: 1.262 g/cm₃
• LogP: 1.27030

Purity/Quality:

98%min ^*data from raw suppliers

6-Methoxy-3(2H)-benzofuranone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Methoxy-3(2H)-benzofuranone

There total 23 articles about 6-Methoxy-3(2H)-benzofuranone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-acetoxy-6-methoxy-benzofuran (415714-37-3) → 6-methoxy-3-coumaranone (15832-09-4)

Guidance literature:

With hydrogenchloride; In methanol; water; Reflux; Inert atmosphere;

DOI:10.1016/j.tet.2021.132117

Reference yield: 93.0%

6-hydroxybenzofuran-3-one (6272-26-0) + methyl iodide (74-88-4) → 6-methoxy-3-coumaranone (15832-09-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.07.012

Reference yield: 86.0%

6-hydroxybenzofuran-3-one (6272-26-0) + dimethyl sulfate (77-78-1) → 6-methoxy-3-coumaranone (15832-09-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.833333h;

DOI:10.3390/molecules24020279

upstream raw materials:

diazomethane

diethyl ether

2-acetoxy-4-methoxy-benzoyl chloride

3-methoxyphenoxyacetic acid

Downstream raw materials:

(αRS,βSR)-2-(α-hydroxybenzyl)-2,6-dimethoxybenzo[b]furan-3(2H)-one

Refernces

• 1、 Balakrishna,Rao,Seshadri. "". . p. 394,401. Retrieved 1949.
• 2、 Scuiller, Ana?s,Liu, Xueyang,Cordier, Marie,Garrec, Julian,Archambeau, Alexis. "A Palladium-Catalyzed Oxa-(4+4)-Cycloaddition Strategy towards Oxazocine Scaffolds". supporting information. p. 981 - 986. Retrieved 2021/06/02.