1,2,4-Triazine-3-carboxylic acid

Base Information

• Chemical Name: 1,2,4-Triazine-3-carboxylic acid
• CAS No.: 6498-04-0
• Molecular Formula: C4H3N3O2
• Molecular Weight: 125.087
• Hs Code.: 2933699090
• Mol file: 6498-04-0.mol

Synonyms:as-Triazine-3-carboxylicacid (7CI,8CI);

Chemical Property of 1,2,4-Triazine-3-carboxylic acid

Chemical Property:

• Boiling Point: 402.6 °C at 760 mmHg
• PKA: 2.35±0.10(Predicted)
• Flash Point: 197.3 °C
• PSA: 75.97000
• Density: 1.532 g/cm³
• LogP: -0.43020

Purity/Quality:

99.3% ^*data from raw suppliers

Sodium1,2,4-Triazine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,4-Triazine-3-carboxylic acid

There total 2 articles about 1,2,4-Triazine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl 1,2,4-triazine-3-carboxylate (6498-02-8) → 1,2,4-triazine-3-carboxylic acid (6498-04-0)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 1h;

DOI:10.1002/cbic.201700185

Reference yield:

→ 1,2,4-triazine-3-carboxylic acid (6498-04-0)

Guidance literature:

1.2.4-Triazin-3-carbonsaeure-ethylester, alkohol. KOH-Lsg.;

DOI:10.1021/jo01344a013

Reference yield: 32.0%

i-propyl isocyanide (598-45-8) + benzaldehyde (100-52-7) + Propargylamine (2450-71-7) + 1,2,4-triazine-3-carboxylic acid (6498-04-0) → C18H19N3O2 (1193371-19-5)

Guidance literature:

In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2009.07.036

upstream raw materials:

ethyl 1,2,4-triazine-3-carboxylate

Downstream raw materials:

1,2,4-triazine

C₂₇H₂₇N₃O₂

C₁₈H₁₉N₃O₂

Refernces

• 1、 Palmer, Andreas Marc,Grobbel, Burkhard,Brehm, Christof,Zimmermann, Peter Jan,Buhr, Wilm,Feth, Martin Philipp,Holst, Hans Christof,Simon, Wolfgang Alexander. "Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion". . p. 7647 - 7660. Retrieved 2008/03/28.