Phenyl(pyridin-2-yl)methanamine hydrochloride

Base Information

• Chemical Name: Phenyl(pyridin-2-yl)methanamine hydrochloride
• CAS No.: 59575-91-6
• Molecular Formula: C₁₂H₁₂N₂*2ClH
• Molecular Weight: 257.163
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90379479
• Mol file: 59575-91-6.mol

Synonyms:59575-91-6;phenyl(pyridin-2-yl)methanamine hydrochloride;1-Phenyl-1-pyridin-2-ylmethanamine hydrochloride;phenyl(pyridin-2-yl)methanamine;hydrochloride;Phenyl(pyridin-2-yl)methanamine HCl;PHENYL(2-PYRIDYL)METHYLAMINE HYDROCHLORIDE;SCHEMBL1421214;DTXSID90379479;MFCD00102147;AS-31413;LS-131664;phenyl(pyridin-2-yl)methanaminehydrochloride;CS-0454048;FT-0744018;EN300-110454;phenyl(2-pyridyl)methylamine hydrochloride, AldrichCPR;5-Hydroxy-2-methyl-naphtho[1,2-b]furan-3-carboxylicacid

Chemical Property of Phenyl(pyridin-2-yl)methanamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.000536mmHg at 25°C
• Melting Point: 226-228 ºC
• Boiling Point: 312.2°C at 760 mmHg
• Flash Point: 163.3°C
• PSA: 38.91000
• LogP: 3.63200
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 220.0767261
• Heavy Atom Count: 15
• Complexity: 164

Purity/Quality:

99% ^*data from raw suppliers

Phenyl(pyridin-2-yl)methanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xn
• Statements: 36/37/38-34-22
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=N2)N.Cl

Technology Process of Phenyl(pyridin-2-yl)methanamine hydrochloride

There total 2 articles about Phenyl(pyridin-2-yl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloropyridine (109-09-1) + N-benzylxanthone imine (6229-07-8) → (phenyl-2-pyridylmethyl)amine dihydrochloride (52095-57-5,59575-91-6)

Guidance literature:

2-chloropyridine; N-benzylxanthone imine; With bis(η3-allyl-μ-chloropalladium(II)); cesiumhydroxide monohydrate; tricyclohexylphosphine; In 5,5-dimethyl-1,3-cyclohexadiene; for 24h; Reflux; Inert atmosphere;

With hydrogenchloride; sodium cyanoborohydride; In ethanol; water; at 25 ℃; for 2h;

With hydrogenchloride; In ethanol; water; at 25 ℃; for 2h;

DOI:10.1016/j.tet.2009.02.034

Reference yield:

1-phenyl-1-(pyridin-2-yl)methanamine (39930-11-5) → (phenyl-2-pyridylmethyl)amine dihydrochloride (52095-57-5,59575-91-6)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol802070d

Reference yield: 40.0%

(phenyl-2-pyridylmethyl)amine dihydrochloride (52095-57-5,59575-91-6) + acetic acid (64-19-7,77671-22-8) → N-(phenyl-2-pyridylmethyl)acetamide (75427-26-8)

Guidance literature:

for 18h; Heating;

DOI:10.1039/P19800000959

upstream raw materials:

1-phenyl-1-(pyridin-2-yl)methanamine

2-chloropyridine

N-benzylxanthone imine

Downstream raw materials:

3-phenyl-1-methylimidazol[1,5-a]pyridine

N-(phenyl-2-pyridylmethyl)acetamide

Refernces

• 1、 Niwa, Takashi,Yorimitsu, Hideki,Oshima, Koichiro. "Palladium-catalyzed benzylic arylation of N-benzylxanthone imine". supporting information; experimental part. p. 4689 - 4691. Retrieved 2009/05/13.