Technology Process of (2S,5R)-5-(2-chlorophenyl)-1-(2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carbonitrile
There total 12 articles about (2S,5R)-5-(2-chlorophenyl)-1-(2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,3,5-trichloro-2,4,6-triazine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol; water / 100 °C / Inert atmosphere
2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 - 50 °C
3.1: HATU / acetonitrile / 0.08 h / 20 °C
3.2: 96 h / 20 °C
4.1: lithium hydroxide; water / tetrahydrofuran / 20 °C
5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C
5.2: 0.02 h / 20 °C
6.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; water; sodium carbonate; HATU; 1,1'-carbonyldiimidazole; lithium hydroxide;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
1.1: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol; water / 100 °C / Inert atmosphere
2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 - 50 °C
3.1: HATU / acetonitrile / 0.08 h / 20 °C
3.2: 96 h / 20 °C
4.1: lithium hydroxide; water / tetrahydrofuran / 20 °C
5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C
5.2: 0.02 h / 20 °C
6.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; water; sodium carbonate; HATU; 1,1'-carbonyldiimidazole; lithium hydroxide;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
1.1: |Suzuki Coupling;