Propionic acid, 2-[p-(benzyloxy)phenoxy]- (6CI)

Base Information

• Chemical Name: Propionic acid, 2-[p-(benzyloxy)phenoxy]- (6CI)
• CAS No.: 59058-37-6
• Molecular Formula: C16H16 O4
• Molecular Weight: 272.3
• Mol file: 59058-37-6.mol

Synonyms:Propionicacid, 2-[p-(benzyloxy)phenoxy]- (6CI)

Chemical Property of Propionic acid, 2-[p-(benzyloxy)phenoxy]- (6CI)

Chemical Property:

• Boiling Point: 440.2±25.0 °C(Predicted)
• PKA: 3.28±0.10(Predicted)
• PSA: 55.76000
• Density: 1.204±0.06 g/cm3(Predicted)
• LogP: 3.11750

Purity/Quality:

98% ^*data from raw suppliers

2-[4-(Benzyloxy)phenoxy]propanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propionic acid, 2-[p-(benzyloxy)phenoxy]- (6CI)

There total 2 articles about Propionic acid, 2-[p-(benzyloxy)phenoxy]- (6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-Benzyloxyphenol (103-16-2) + 2-Bromopropionic acid (598-72-1,10327-08-9) → (R,S)-2-<4-(Benzyloxy)phenoxy>propanoic acid (59058-37-6)

Guidance literature:

With sodium hydroxide; In ethanol; at 55 - 60 ℃; for 4h;

Reference yield:

→ (R,S)-2-<4-(Benzyloxy)phenoxy>propanoic acid (59058-37-6)

Guidance literature:

aequimolare Mengen Natrium-<4-benzyloxyphenolat> und Natrium-<2-brom-propionat>, wss. Lsg., Erwaermen, 1-2 h;

Reference yield:

(R,S)-2-<4-(Benzyloxy)phenoxy>propanoic acid (59058-37-6) → n-butyl 2-(4-hydroxyphenoxy)propionate (81947-94-6)

Guidance literature:

Multi-step reaction with 3 steps

1: (COCl)2, DMF / benzene / 24 h / Ambient temperature

2: 4-N,N-dimethylaminopyridine, Et₃N / CH₂Cl₂ / 1.) O deg C, 1 h, 2.) room temp., overnight

3: 62 percent / H₂ / 5percent Pd/C / ethyl acetate / Ambient temperature

With dmap; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In dichloromethane; ethyl acetate; benzene;

upstream raw materials:

4-Benzyloxyphenol

2-Bromopropionic acid

Downstream raw materials:

2-(4-benzyloxy-phenoxy)-propionyl chloride

n-butyl 2-(4-hydroxyphenoxy)propionate

(R, S)-propyl 4-(2-hydroxyphenoxy)propanoate

Propyl (R,S)-2-<4-(benzyloxy)phenoxy>propanoate

Refernces