(S)-(+)-1-Benzyloxy-2-propanol

Base Information

• Chemical Name: (S)-(+)-1-Benzyloxy-2-propanol
• CAS No.: 85483-97-2
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.22
• Hs Code.: 2909499000
• European Community (EC) Number: 627-014-5
• Nikkaji Number: J781.051B
• Mol file: 85483-97-2.mol

Synonyms:85483-97-2;(S)-(+)-1-Benzyloxy-2-propanol;(S)-1-(benzyloxy)propan-2-ol;(s)-1-benzyloxy-2-propanol;(2S)-1-phenylmethoxypropan-2-ol;2-Propanol, 1-(phenylmethoxy)-, (2S)-;(2S)-1-benzyloxypropan-2-ol;MFCD07367008;(S)-1-O-Benzylpropylene glycol;SCHEMBL2181772;KJBPYIUAQLPHJG-VIFPVBQESA-N;(2S)-1-(benzyloxy)propan-2-ol;(S)-1-benzyloxy-2-hydroxypropane;AMY37532;(+)-(S)-1-benzyloxy-2-propanol;AKOS016843866;CS-W017736;DS-4548;Benzyl (S)-(+)-2-Hydroxypropyl Ether;(S)-(+)-1-Benzyloxy-2-propanol, 97%;B4117;A11414;(S)-(+)-1-BENZYLOXY-2-PROPANOL 97;EN300-6446057

Chemical Property of (S)-(+)-1-Benzyloxy-2-propanol

Chemical Property:

• Vapor Pressure: 0.00505mmHg at 25°C
• Refractive Index: n20/D 1.510(lit.)
• Boiling Point: 263.8 °C at 760 mmHg
• PKA: 14.46±0.20(Predicted)
• Flash Point: 108.2 °C
• PSA: 29.46000
• Density: 1.042 g/cm³
• LogP: 1.58400
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 166.099379685
• Heavy Atom Count: 12
• Complexity: 108

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-(+)-1-Benzyloxy-2-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(COCC1=CC=CC=C1)O
• Isomeric SMILES: C[C@@H](COCC1=CC=CC=C1)O
• Uses: (S)-(+)-1-Benzyloxy-2-propanol can be used as a reactant to prepare: (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases (PMP derivatives). (S)-1-(benzyloxy)propan-2-yl 4-methylbenzenesulfonate by reacting with tosyl chloride in pyridine.

Technology Process of (S)-(+)-1-Benzyloxy-2-propanol

There total 18 articles about (S)-(+)-1-Benzyloxy-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(2S)-1-benzyloxy-2-propanyl tetrahydropyran-2-yl ether (85483-96-1) → (2S)-1-(benzyloxy)propan-2-ol (13807-91-5,89401-28-5,103129-25-5,85483-97-2)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 0 - 20 ℃;

DOI:10.1002/asia.201000528

Reference yield: 89.0%

(R)-1-Benzyloxy-3-phenylsulfanyl-propan-2-ol → (2S)-1-(benzyloxy)propan-2-ol (13807-91-5,89401-28-5,103129-25-5,85483-97-2)

Guidance literature:

With sodium hypophosphite; Raney-Ni (W-2); In ethanol; water; for 0.5h; Ambient temperature; pH=5.2;

DOI:10.1016/S0040-4020(97)00804-1

Reference yield: 87.0%

(R)-1-Benzyloxy-3-benzylsulfanyl-propan-2-ol → (2S)-1-(benzyloxy)propan-2-ol (13807-91-5,89401-28-5,103129-25-5,85483-97-2)

Guidance literature:

With sodium hypophosphite; Raney-Ni (W-2); In ethanol; water; for 0.5h; Ambient temperature; pH=5.2;

DOI:10.1016/S0040-4020(97)00804-1

upstream raw materials:

3-benzyloxypropanone

(S)-1,2-Propanediol

benzyl bromide

(2S)-1-benzyloxy-2-propanyl tetrahydropyran-2-yl ether

Downstream raw materials:

(S)-27-methyl-28-benzyloxy-2,5,8,11,14,17,20,23,26-nonaoxaoctacosane

(S)-(-)-(2-benzyloxy-1-methyl)ethyl 4-methyl-benzenesulfonate

benzyloxy-2-propanol

Refernces

• 1、 -. "Double-hetero atom six-membered ring of synthetic method". . . Retrieved 2018/07/30.
• 2、 Yang, Chu-Ting,Zhang, Zhen-Qi,Liang, Jun,Liu, Jing-Hui,Lu, Xiao-Yu,Chen, Huan-Huan,Liu, Lei. "Copper-catalyzed cross-coupling of nonactivated secondary alkyl halides and tosylates with secondary alkyl grignard reagents". supporting information; experimental part. p. 11124 - 11127. Retrieved 2012/08/28.