2-ACETYL-4-NITROTHIOPHENE

Base Information

• Chemical Name: 2-ACETYL-4-NITROTHIOPHENE
• CAS No.: 42791-51-5
• Molecular Formula: C₆H₅NO₃S
• Molecular Weight: 171.177
• Hs Code.: 2934999090
• Mol file: 42791-51-5.mol

Synonyms:2-Acetyl-4-nitrothiophene;Ketone, methyl 4-nitro-2-thienyl (6CI,7CI);

Chemical Property of 2-ACETYL-4-NITROTHIOPHENE

Chemical Property:

• Vapor Pressure: 0.00368mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 280.9 °C at 760 mmHg
• Flash Point: 123.7 °C
• PSA: 91.13000
• Density: 1.399 g/cm³
• LogP: 2.38210
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Nitrothiophen-2-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ACETYL-4-NITROTHIOPHENE

There total 11 articles about 2-ACETYL-4-NITROTHIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Acetylthiophene (88-15-3,97511-16-5) → 2-acetyl-4-nitrothiophene (42791-51-5)

Guidance literature:

With sulfuric acid; nitric acid; In water; at -10 ℃; for 5h;

Reference yield:

5-Acetyl-3-nitro-thiophene-2-carboxylic acid → 2-acetyl-4-nitrothiophene (42791-51-5)

Guidance literature:

With copper; In quinoline; at 260 ℃;

DOI:10.1016/0223-5234(91)90207-4

Reference yield:

5-acetylthiophene-2-carbaldehyde (4565-29-1) → 2-acetyl-4-nitrothiophene (42791-51-5)

Guidance literature:

Multi-step reaction with 3 steps

1: HNO₃, H₂SO₄ / -10 °C

2: Na₂Cr₂O₇, H₂SO₄

3: Cu / quinoline / 260 °C

With sodium dichromate; sulfuric acid; nitric acid; copper; In quinoline;

DOI:10.1016/0223-5234(91)90207-4

upstream raw materials:

2-Acetylthiophene

acetic anhydride

4-nitro-2-thiophenecarboxylic acid

sodium ethyl acetylacetate enolate

Downstream raw materials:

2-acetyl-4-amino-thiophene

1-(4-nitro-[2]thienyl)-ethanone-(4-bromo-phenylhydrazone)

Refernces

• 1、 -. "COMPOSITIONS USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES". Page 109. . Retrieved 2010/02/07.
• 2、 Arnone, Caterina,Consiglio, Giovanni,Spinelli, Domenico,Dell'Erba, Carlo,Sancassan, Fernando,Terrier, Francois. "Meisenheimer-type Adducts from Thiophene Derivates. Part 6. A Kinetic and Thermodynamic Study of Substituent Effects on the Formation of Some non-gem Adducts". . p. 1609 - 1612. Retrieved 2007/10/02.