3-Aminopicolinaldehyde

Base Information

• Chemical Name: 3-Aminopicolinaldehyde
• CAS No.: 55234-58-7
• Molecular Formula: C6H6N2O
• Molecular Weight: 122.126
• Hs Code.: 2933399090
• European Community (EC) Number: 966-679-9
• DSSTox Substance ID: DTXSID50480338
• Nikkaji Number: J886.529I
• Wikidata: Q72441519
• Mol file: 55234-58-7.mol

Synonyms:3-Aminopicolinaldehyde;55234-58-7;3-Amino-pyridine-2-carbaldehyde;3-Aminopyridine-2-carbaldehyde;3-Aminopyridine-2-carboxaldehyde;2-Pyridinecarboxaldehyde, 3-amino-;3-AMINO-2-PYRIDINECARBALDEHYDE;MFCD07776828;3-Amino-2-formylpyridine;SCHEMBL1501696;SCHEMBL4661725;DTXSID50480338;QNJCRBZVUFRESB-UHFFFAOYSA-N;AMY19104;AKOS006229331;AB42378;AS-41301;SY258410;CS-0157032;FT-0659929;EN300-180052;A830549

Chemical Property of 3-Aminopicolinaldehyde

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 118-120°C
• Refractive Index: 1.652
• Boiling Point: 302.638 °C at 760 mmHg
• PKA: 4.68±0.10(Predicted)
• Flash Point: 136.831 °C
• PSA: 55.98000
• Density: 1.264 g/cm³
• LogP: 1.05750
• Storage Temp.: Refrigerator
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 122.048012819
• Heavy Atom Count: 9
• Complexity: 105

Purity/Quality:

98%min ^*data from raw suppliers

3-Aminopyridine-2-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)C=O)N

Technology Process of 3-Aminopicolinaldehyde

There total 9 articles about 3-Aminopicolinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-amino-2-hydroxy-methylpyridine (52378-63-9) → 3-aminopyridine-2-carboxaldehyde (55234-58-7)

Guidance literature:

With manganese(IV) oxide; In chloroform; for 24h; Ambient temperature;

DOI:10.1002/jhet.5570290525

Reference yield: 80.3%

(2?formyl?pyridin?3?yl)?carbamic acid tert?butyl ester (116026-99-4) → 3-aminopyridine-2-carboxaldehyde (55234-58-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield: 50.0%

C7H8N2O4 → 3-aminopyridine-2-carboxaldehyde (55234-58-7)

Guidance literature:

With hydrogen; palladium on carbon; In ethanol; Inert atmosphere;

upstream raw materials:

3-amino-2-hydroxy-methylpyridine

ethyl 3-aminopyridine-2-carboxylate

3-nitropyridine-2-carboxaldehyde

2-Chloro-3-nitropyridine

Downstream raw materials:

methyl (2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol

2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione

N-(1-(2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)ethyl)-9H-purin-6-amine

2-(3-fluorophenyl)-1,5-naphthyridine-3-carbaldehyde

Refernces

• 1、 Zhang, Jianwei,Chen, Fei,He, Yan-Mei,Fan, Qing-Hua. "Asymmetric Ruthenium-Catalyzed Hydrogenation of 2,6-Disubstituted 1,5-Naphthyridines: Access to Chiral 1,5-Diaza-cis-Decalins". supporting information. p. 4622 - 4625. Retrieved 2015/04/14.
• 2、 Chen,Deady. "Synthesis of some benzo[b][1,8] and [1,5]naphthyridines". . p. 1197 - 1201. Retrieved 2007/10/02.