3-Benzyloxy-4-Methylbenzoic Acid

Base Information

• Chemical Name: 3-Benzyloxy-4-Methylbenzoic Acid
• CAS No.: 165662-68-0
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.274
• Mol file: 165662-68-0.mol

Synonyms:3-(Benzyloxy)-4-methylbenzoic acid;4-Methyl-3-(phenylmethoxy)benzoic acid;

Chemical Property of 3-Benzyloxy-4-Methylbenzoic Acid

Chemical Property:

• Vapor Pressure: 7.02E-08mmHg at 25°C
• Refractive Index: 1.597
• Boiling Point: 422.1 °C at 760 mmHg
• Flash Point: 160 °C
• PSA: 46.53000
• Density: 1.193 g/cm³
• LogP: 3.27220
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Benzyloxy-4-methylbenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Benzyloxy-4-Methylbenzoic Acid

There total 2 articles about 3-Benzyloxy-4-Methylbenzoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-(benzyloxy)-4-methylbenzoic acid (165662-68-0) + 3-benzyloxy-4-methyl-benzoyl chloride

Guidance literature:

Reference yield:

methyl 4-methyl-3-hydroxybenzoate (3556-86-3) → 3-(benzyloxy)-4-methylbenzoic acid (165662-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: lithium hydroxide; water / tetrahydrofuran / 8 h / 20 °C

With water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 13.0%

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (641571-11-1) + 3-(benzyloxy)-4-methylbenzoic acid (165662-68-0) → 3-(benzyloxy)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Guidance literature:

3-(benzyloxy)-4-methylbenzoic acid; With thionyl chloride; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 1h;

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline; With triethylamine; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 3h;

upstream raw materials:

methyl 4-methyl-3-hydroxybenzoate

Downstream raw materials:

(3-(benzyloxy)-4-methylphenyl)methanol

3-(benzyloxy)-4-methylbenzaldehyde

Refernces

• 1、 -. "Anthracene derivatives". . . Retrieved 2008/06/13.