3-METHYL-4-PIPERIDONE

Base Information

• Chemical Name: 3-METHYL-4-PIPERIDONE
• CAS No.: 5773-58-0
• Molecular Formula: C6 H11 N O
• Molecular Weight: 113.159
• Hs Code.: 2933399090
• Mol file: 5773-58-0.mol

Synonyms:4-Piperidone,3-methyl- (6CI,7CI,8CI);3-Methyl-4-piperidone;3-Methylpiperidin-4-one;AKOS BC-0319;

Chemical Property of 3-METHYL-4-PIPERIDONE

Chemical Property:

• Vapor Pressure: 0.803mmHg at 25°C
• Refractive Index: 1.438
• Boiling Point: 182.631 °C at 760 mmHg
• PKA: 8.98±0.40(Predicted)
• Flash Point: 81.781 °C
• PSA: 29.10000
• Density: 0.951g/cm³
• LogP: 0.51370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-methylpiperidin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYL-4-PIPERIDONE

There total 3 articles about 3-METHYL-4-PIPERIDONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-Benzyl-3-methyl-4-piperidon (34737-89-8) → 3-methyl-4-piperidone (5773-58-0)

Guidance literature:

With palladium dihydroxide; hydrogen; In ethanol; for 24h; under 2637.5 Torr; Ambient temperature;

DOI:10.1002/jlcr.2580361102

Reference yield: 75.0%

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate (181269-69-2) → 3-methyl-4-piperidone (5773-58-0)

Guidance literature:

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With water; In dichloromethane; water;

Reference yield:

5-diethylamino-2-methyl-pent-1-en-3-one (91016-40-9) → 3-methyl-4-piperidone (5773-58-0)

Guidance literature:

With ammonia; mit fluessigem Ammoniak;

DOI:10.1016/S0378-7753(01)00965-X

upstream raw materials:

5-diethylamino-2-methyl-pent-1-en-3-one

1-Benzyl-3-methyl-4-piperidon

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Downstream raw materials:

C₁₉H₃₅NO₃

C₁₃H₁₆ClNO

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

Refernces

• 1、 -. "AMINOPIPERIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF". Page/Page column 25. . Retrieved 2010/11/28.
• 2、 -. "HETEROARYLPIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY". Page 74. . Retrieved 2008/06/13.