Technology Process of 2-[4-[4-(3-Pyridinyl)-1H-imidazol-1-yl]butyl]-1H-isoindole-1,3(2H)-dione
There total 6 articles about 2-[4-[4-(3-Pyridinyl)-1H-imidazol-1-yl]butyl]-1H-isoindole-1,3(2H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydroxylamine hydrochloride / methanol / 5 h / Reflux
2: pyridine / 16 h / 0 - 20 °C
3: potassium ethoxide / ethanol / 9 h / 0 - 20 °C
4: toluene-4-sulfonic acid / water / 5 h / 50 °C
5: nitric acid / 2 h / 90 °C
6: potassium carbonate / N,N-dimethyl-formamide / 10 h / 90 °C
With
pyridine; hydroxylamine hydrochloride; potassium ethoxide; nitric acid; potassium carbonate; toluene-4-sulfonic acid;
In
methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1080/10286020.2018.1462341
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine / 16 h / 0 - 20 °C
2: potassium ethoxide / ethanol / 9 h / 0 - 20 °C
3: toluene-4-sulfonic acid / water / 5 h / 50 °C
4: nitric acid / 2 h / 90 °C
5: potassium carbonate / N,N-dimethyl-formamide / 10 h / 90 °C
With
pyridine; potassium ethoxide; nitric acid; potassium carbonate; toluene-4-sulfonic acid;
In
ethanol; water; N,N-dimethyl-formamide;
DOI:10.1080/10286020.2018.1462341