METHYL 2-BROMOVALERATE

Base Information

• Chemical Name: METHYL 2-BROMOVALERATE
• CAS No.: 19129-92-1
• Molecular Formula: C₆H₁₁BrO₂
• Molecular Weight: 195.056
• Hs Code.: 2915900090
• Mol file: 19129-92-1.mol

Synonyms:2-Bromovaleric acid methylester;Valericacid, 2-bromo-, methyl ester (6CI,8CI);Methyl a-bromovalerate;Methyl a-bromopentanoate;

Chemical Property of METHYL 2-BROMOVALERATE

Chemical Property:

• Vapor Pressure: 0.944mmHg at 25°C
• Refractive Index: 1.455
• Boiling Point: 179.372 °C at 760 mmHg
• Flash Point: 69.549 °C
• PSA: 26.30000
• Density: 1.349 g/cm³
• LogP: 1.72300
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Methyl-2-bromopentanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl-2-bromopentanoate is a reagent used in the synthesis of oxazepinones and substituted benzofurans

Technology Process of METHYL 2-BROMOVALERATE

There total 9 articles about METHYL 2-BROMOVALERATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 2-bromopentanoyl chloride (42768-45-6) → methyl 2-bromovalerate (19129-92-1,114438-77-6,114438-78-7)

Guidance literature:

DOI:10.1016/S0022-1139(01)00443-2

Reference yield: 41.0%

methanol (67-56-1) + ((Z)-1-Chloro-pent-1-enylsulfanyl)-benzene (83818-64-8) → methyl 2-bromovalerate (19129-92-1,114438-77-6,114438-78-7)

Guidance literature:

With bromine; at -45 ℃; for 2h;

Reference yield:

methyl valerate (624-24-8) → 5-bromovaleric acid methyl ester (5454-83-1) + methyl 2-bromovalerate (19129-92-1,114438-77-6,114438-78-7) + methyl 4-bromopentanoate (75411-76-6) + Methyl-β-brom-valerat (77085-21-3)

Guidance literature:

With dimethyl-N-bromoamine; sulfuric acid; iron(II) sulfate;

DOI:10.1039/c19670000903

upstream raw materials:

methanol

2-Bromovaleric acid

methyl valerate

2-bromopentanoyl chloride

Downstream raw materials:

α-phenylthio methyl pentanoate

3,6-diphenyl-5-propyl-1H-pyrimidine-2,4-dione

methyl 2-(2,3-dimethyl)-phenoxyvalerianate

C₃₀H₃₆ClNO₅S

Refernces

• 1、 Minisci, Francesco,Porta, Ombretta,Recupero, Francesco,Gambarotti, Cristian,Paganelli, Roberto,Pedulli, Gian Franco,Fontana, Francesca. "New free-radical halogenations of alkanes, catalysed by N-hydroxyphthalimide. Polar and enthalpic effects on the chemo- and regioselectivity". . p. 1607 - 1609. Retrieved 2007/10/03.
• 2、 Fortes, C. C.,Chaves, M. H.. "SOLVOLYSIS OF 1-CHLORO-1-ALKENYL PHENYL SULFIDES. SYNTHESIS OF α-BROMO PHENYL THIOCARBOXYLIC ESTERS, α-BROMO ALKYL CARBOXYLIC ESTERS AND α-PHENYLTHIO METHYL CARBOXYLIC ESTERS". . p. 751 - 762. Retrieved 2007/10/02.