Methyl 3-bromo-2-bromomethylbenzoate

Base Information

• Chemical Name: Methyl 3-bromo-2-bromomethylbenzoate
• CAS No.: 337536-14-8
• Molecular Formula: C9H8Br2O2
• Molecular Weight: 307.969
• Hs Code.: 2916399090
• Mol file: 337536-14-8.mol

Synonyms:3-Bromo-2-bromomethylbenzoicacid methyl ester;Methyl 3-bromo-2-bromomethylbenzoate;benzoic acid, 3-bromo-2-(bromomethyl)-, methyl ester;

Chemical Property of Methyl 3-bromo-2-bromomethylbenzoate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.59
• Boiling Point: 344.897 °C at 760 mmHg
• Flash Point: 162.388 °C
• PSA: 26.30000
• Density: 1.780 g/cm³
• LogP: 3.13060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

Methyl 3-bromo-2-(bromomethyl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-bromo-2-bromomethylbenzoate

There total 6 articles about Methyl 3-bromo-2-bromomethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-bromo-2-methylbenzoate (99548-54-6) → methyl 3-bromo-2-(bromomethyl)benzoate (337536-14-8)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In benzene; for 5h; Heating / reflux;

Reference yield:

azobisisobutyronitrile (34241-39-9) + methyl 3-bromo-2-methylbenzoate (99548-54-6) → methyl 3-bromo-2-(bromomethyl)benzoate (337536-14-8)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane;

Reference yield:

methyl 3-bromo-2-methylbenzoate (99548-54-6) + methyl 2-methyl-5-bromobenzoate (79669-50-4) → methyl 2-bromomethyl-5-bromobenzoate (79670-17-0) + methyl 3-bromo-2-(bromomethyl)benzoate (337536-14-8)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 20h; Heating / reflux;

upstream raw materials:

methyl 3-bromo-2-methylbenzoate

3-bromo-2-methylbenzoic acid chloride

3-bromo-2-methylbenzoic acid

azobisisobutyronitrile

Downstream raw materials:

3-(4-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione

4-bromo-2,3-dihydro-1H-isoindole hydrochloride

Refernces

• 1、 -. "BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY". Paragraph 0452-0453; 0702-0703. . Retrieved 2021/05/15.
• 2、 Wang, Siyuan,Zhou, Yangkun,Huang, Hanmin. "Palladium-Catalyzed Tandem Carbonylative Diels-Alder Reaction for Construction of Bridged Polycyclic Skeletons". supporting information. p. 2125 - 2129. Retrieved 2021/04/05.