diphenyl iodomethyl phosphine oxide

Base Information

• Chemical Name: diphenyl iodomethyl phosphine oxide
• CAS No.: 31238-55-8
• Molecular Formula: C₁₃H₁₂IOP
• Molecular Weight: 342.116
• Mol file: 31238-55-8.mol

Synonyms:diphenyl iodomethyl phosphine oxide

Chemical Property of diphenyl iodomethyl phosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diphenyl iodomethyl phosphine oxide

There total 8 articles about diphenyl iodomethyl phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(diphenylphosphoryl)methyl p-toluenesulfonate (33730-69-7) → diphenyl iodomethyl phosphine oxide (31238-55-8)

Guidance literature:

With sodium iodide; In acetone; at 75 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201001471

Reference yield: 71.0%

diphenyl(chloromethyl)phosphine oxide (1806-49-1) → diphenyl iodomethyl phosphine oxide (31238-55-8)

Guidance literature:

With potassium iodide; In N,N-dimethyl-formamide; for 2h; Heating;

Reference yield:

(diphenylphosphinoyl)methanol (884-74-2) → diphenyl iodomethyl phosphine oxide (31238-55-8)

Guidance literature:

Multi-step reaction with 2 steps

2: KI / dimethylformamide / Heating

With potassium iodide; In N,N-dimethyl-formamide;

upstream raw materials:

diphenyl(chloromethyl)phosphine oxide

(diphenylphosphoryl)methyl p-toluenesulfonate

diphenyl(methyl)phosphine oxide

(diphenylphosphinoyl)methanol

Downstream raw materials:

1-(Diphenyl-phosphinoylmethoxy)-4-nitro-benzene

5,11,17,23-tetra-tert-butyl-25-(diphenylphosphinoylmethoxy)-26,27,28-trihydroxycalix[4]arene

(2-cyclopropylethyl)diphenylphosphine oxide

(2-methylbut-3-en-1-yl)diphenylphosphine oxide

Refernces

• 1、 Tkachenko, S. E.,Yarkevich, A. N.,Timofeev, S. V.,Tsvetkov, E. N.. "INFLUENCE OF THE LEAVING GROUP ON REACTIVITY OF HALOMETHYLDIPHENYLPHOSPHINE OXIDES IN THE WILLIAMSON SYNTHESIS". . p. 465 - 469. Retrieved 2007/10/02.
• 2、 Imamoto, Tsuneo,Koto, Hiroyasu. "An Efficient Synthesis of α-Iodo Derivatives of Sulfones, Sulfoximines, and Phosphine Oxides". . p. 982 - 983. Retrieved 2007/10/02.