2-Amino-N-cyclohexylbenzamide

Base Information

• Chemical Name: 2-Amino-N-cyclohexylbenzamide
• CAS No.: 56814-11-0
• Molecular Formula: C13H18N2O
• Molecular Weight: 218.299
• Hs Code.: 2924299090
• European Community (EC) Number: 673-042-6
• DSSTox Substance ID: DTXSID70341997
• Wikidata: Q82112518
• Mol file: 56814-11-0.mol

Synonyms:2-Amino-N-cyclohexylbenzamide;56814-11-0;2-Amino-N-cyclohexyl-benzamide;Maybridge1_003298;Oprea1_673490;SCHEMBL2154833;HMS550N20;DTXSID70341997;2-amino-N~1~-cyclohexylbenzamide;BBL001797;MFCD00060339;STK125810;AKOS000111774;PS-4210;BB 0246459;CS-0312600;FT-0640412;A831185;SR-01000530925;SR-01000530925-1

Chemical Property of 2-Amino-N-cyclohexylbenzamide

Chemical Property:

• Vapor Pressure: 2.59E-07mmHg at 25°C
• Melting Point: 153-156 °C
• Refractive Index: 1.575
• Boiling Point: 421.5 °C at 760 mmHg
• PKA: 14.31±0.20(Predicted)
• Flash Point: 208.7 °C
• PSA: 55.12000
• Density: 1.11 g/cm³
• LogP: 3.30340
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 218.141913202
• Heavy Atom Count: 16
• Complexity: 236

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-N-cyclohexylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)NC(=O)C2=CC=CC=C2N

Technology Process of 2-Amino-N-cyclohexylbenzamide

There total 12 articles about 2-Amino-N-cyclohexylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ anthranilic acid cyclohexylamine (56814-11-0)

Guidance literature:

Reference yield: 88.0%

isatoic anhydride (118-48-9) + cyclohexylamine (108-91-8,157973-60-9) → anthranilic acid cyclohexylamine (56814-11-0)

Guidance literature:

With aqueous extract of mesocarp of fruit of Balanites roxburghii plant; at 60 ℃; for 0.25h;

DOI:10.1039/c4ra09514f

Reference yield: 65.0%

cyclohexylamine (108-91-8,157973-60-9) + 3-(2-oxo-2-phenylethyl)quinazolin-4(3H)-one (60007-51-4) → anthranilic acid cyclohexylamine (56814-11-0) + 1-cyclohexyl-5-phenyl-1H-imidazole (71333-68-1)

Guidance literature:

With toluene-4-sulfonic acid; In xylene; for 12h; Heating;

DOI:10.1016/S0040-4020(01)87289-6

upstream raw materials:

isatoic anhydride

cyclohexylamine

3-(2-oxo-2-phenylethyl)quinazolin-4(3H)-one

4-Hydroxyquinazoline

Downstream raw materials:

3-cyclohexylquinazolin-4(3H)-one

3-Cyclohexyl-2-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinine-4-thione

2-((1-acetyl-3-hydroxy-2-oxoindolin-3-yl)amino)-N-cyclohexylbenzamide

3-cyclohexyl-2-(5-ethylthiophen-2-yl)-2,3-dihydroquinazolin-4(1H)-one

Refernces

• 1、 Ding, Chengcheng,Li, Shichen,Ma, Chen,Ren, Jianing,Wang, Yishou. "N,N-Dimethylformamide as Carbon Synthons for the Synthesis ofN-Heterocycles: Pyrrolo/Indolo[1,2-a]quinoxalines and Quinazolin-4-ones". . p. 16848 - 16857. Retrieved 2021/12/06.
• 2、 Biswal, Sonali,Chada, Harika,Patel, Srilaxmi M.,Sharada, Duddu S.,Sharma, Sonika. "Copper-Catalyzed Intramolecular α-C-H Amination via Ring-Opening Cyclization Strategy to Quinazolin-4-ones: Development and Application in Rutaecarpine Synthesis". . p. 3160 - 3170. Retrieved 2019/08/07.