2-AMINO-5-NITROBENZANILIDE

Base Information

• Chemical Name: 2-AMINO-5-NITROBENZANILIDE
• CAS No.: 30481-54-0
• Molecular Formula: C13H11N3O3
• Molecular Weight: 257.249
• Hs Code.: 2924299090
• Mol file: 30481-54-0.mol

Synonyms:Benzanilide, 2-amino-5-nitro- (8CI);

Chemical Property of 2-AMINO-5-NITROBENZANILIDE

Chemical Property:

• Vapor Pressure: 6.15E-07mmHg at 25°C
• Melting Point: 202-204 °C
• Refractive Index: 1.714
• Boiling Point: 410.2 °C at 760 mmHg
• PKA: 12.25±0.70(Predicted)
• Flash Point: 201.9 °C
• PSA: 100.94000
• Density: 1.41 g/cm³
• LogP: 3.60670

Purity/Quality:

98%Min ^*data from raw suppliers

2-Amino-5-nitrobenzanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-NITROBENZANILIDE

There total 6 articles about 2-AMINO-5-NITROBENZANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

aniline (62-53-3) + 2-amino-5-nitro-benzoic acid (616-79-5) → 2-amino-5-nitro-N-phenylbenzamide (30481-54-0)

Guidance literature:

2-amino-5-nitro-benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

aniline; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1002/chem.201905219

Reference yield: 68.0%

6-nitroisatoic anhydride (4693-02-1) + aniline (62-53-3) → 2-amino-5-nitro-N-phenylbenzamide (30481-54-0)

Guidance literature:

With dmap; In dimethyl sulfoxide; at 130 ℃; Sealed tube; Inert atmosphere;

DOI:10.1016/j.bmc.2019.03.026

Reference yield:

2-Amino-5-nitro-benzoyl chloride (69123-71-3) + aniline (62-53-3) → 2-amino-5-nitro-N-phenylbenzamide (30481-54-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2018.12.025

upstream raw materials:

aniline

2-amino-5-nitro-benzoic acid

2-Amino-5-nitro-benzoyl chloride

6-nitroisatoic anhydride

Downstream raw materials:

6-nitro-3-phenyl-4(3H)-quinazolinone

6-nitro-3-phenylquinazoline-2,4(1H,3H)-dione

2-(4-ethylpiperazin-1-yl)-6-nitro-3-phenylquinazolin-4(3H)-one

6-nitro-3-phenylbenzo[d][1,2,3]triazin-4(3H)-one

Refernces

• 1、 Yan, Gang,Zekarias, Bereket L.,Li, Xiaoyu,Jaffett, Victor A.,Guzei, Ilia A.,Golden, Jennifer E.. "Divergent 2-Chloroquinazolin-4(3H)-one Rearrangement: Twisted-Cyclic Guanidine Formation or Ring-Fused N-Acylguanidines via a Domino Process". supporting information. p. 2486 - 2492. Retrieved 2020/02/13.
• 2、 Liu, Shuai,Xu, Liang,Wei, Yu. "One-Pot, Multistep Reactions for the Modular Synthesis of N, N′-Diarylindazol-3-ones". . p. 1596 - 1604. Retrieved 2019/02/07.