1-(2-CHLOROBENZYL)PIPERAZINE

Base Information

• Chemical Name: 1-(2-CHLOROBENZYL)PIPERAZINE
• CAS No.: 17532-19-3
• Molecular Formula: C11H15ClN2
• Molecular Weight: 210.706
• Hs Code.: 29339900
• Mol file: 17532-19-3.mol

Synonyms:Piperazine,1-(o-chlorobenzyl)- (7CI,8CI);1-(2-Chlorobenzyl)piperazine;1-(o-Chlorobenzyl)piperazine;Piperazine, 1-(2-chlorobenzyl)-;Piperazine, 1-[(2-chlorophenyl)methyl]-;

Chemical Property of 1-(2-CHLOROBENZYL)PIPERAZINE

Chemical Property:

• Vapor Pressure: 7.4E-14mmHg at 25°C
• Melting Point: 157 °C
• Refractive Index: 1.462
• Boiling Point: 303.704 °C at 760 mmHg
• PKA: 9.08±0.10(Predicted)
• Flash Point: 137.476 °C
• PSA: 15.27000
• Density: 1.146 g/cm³
• LogP: 2.01190

Purity/Quality:

98% ^*data from raw suppliers

1-(2-Chlorobenzyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-52-36-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-CHLOROBENZYL)PIPERAZINE

There total 10 articles about 1-(2-CHLOROBENZYL)PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl 4-[(2-chlorophenyl)methyl]piperazine-1-carboxylate → 1-(2-chloro-benzyl)-piperazine (17532-19-3)

Guidance literature:

tert-butyl 4-[(2-chlorophenyl)methyl]piperazine-1-carboxylate; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium hydroxide; In water; pH=9;

Reference yield: 81.0%

piperazine (110-85-0) + 1-chloro-2-(chloromethyl)benzene (611-19-8) → 1-(2-chloro-benzyl)-piperazine (17532-19-3)

Guidance literature:

In tetrahydrofuran; for 4h; Reflux;

DOI:10.1016/j.ejmech.2011.01.020

Reference yield:

piperazine (110-85-0) + benzyl chloride (100-44-7) → 1-(2-chloro-benzyl)-piperazine (17532-19-3)

Guidance literature:

piperazine; With sodium hydroxide; In ethanol; at 20 ℃;

benzyl chloride; In ethanol; Reflux;

upstream raw materials:

piperazine

1-chloro-2-(chloromethyl)benzene

4-(2-chloro-benzyl)-piperazine-1-carboxylic acid ethyl ester

2-chloro-benzaldehyde

Refernces

• 1、 Singh, Shalu,Bali, Alka,Peshin, Tania. "Synthesis and evaluation of aryl substituted propyl piperazines for potential atypical antipsychotic activity". . p. 429 - 441. Retrieved 2021/03/26.
• 2、 -. "Piperazine-containing myricetin derivative and preparation method thereof (by machine translation)". Paragraph 0040; 0042; 0043. . Retrieved 2019/08/07.