1,2-Dibromo-5-chloro-3-fluorobenzene

Base Information

• Chemical Name: 1,2-Dibromo-5-chloro-3-fluorobenzene
• CAS No.: 208186-78-1
• Molecular Formula: C6H2Br2ClF
• Molecular Weight: 288.341
• Hs Code.: 2903998090
• DSSTox Substance ID: DTXSID80369283
• Nikkaji Number: J2.343.834H
• Wikidata: Q82156330
• Mol file: 208186-78-1.mol

Synonyms:208186-78-1;1,2-dibromo-5-chloro-3-fluorobenzene;5-Chloro-2,3-dibromo-1-fluorobenzene;1-chloro-3,4-dibromo-5-fluorobenzene;1,2-dibromo-5-chloro-3-fluoro-benzene;MFCD00143441;5-chloro-1,2-dibromo-3-fluorobenzene;SCHEMBL9948439;DTXSID80369283;XLDRDGJJGGYJCO-UHFFFAOYSA-N;AKOS015890108;AM62578;CS-W013998;DS-5196;SY061726;3-Fluoro-5-chloro-1,2-phenylene dibromide;Benzene, 1,2-dibromo-5-chloro-3-fluoro-;FT-0620199;FT-0620228;EN300-6950946;A814945;A844339

Chemical Property of 1,2-Dibromo-5-chloro-3-fluorobenzene

Chemical Property:

• Vapor Pressure: 0.0454mmHg at 25°C
• Melting Point: 37-39°C
• Refractive Index: 1.589
• Boiling Point: 245.3 °C at 760 mmHg
• Flash Point: 102.1 °C
• PSA: 0.00000
• Density: 2.089 g/cm³
• LogP: 4.00410
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 287.81753
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Chloro-2,3-dibromo-1-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1F)Br)Br)Cl

Technology Process of 1,2-Dibromo-5-chloro-3-fluorobenzene

There total 1 articles about 1,2-Dibromo-5-chloro-3-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-bromo-4-chloro-6-fluorobenzenamine (195191-47-0) → 1,2-dibromo-5-chloro-3-fluorobenzene (208186-78-1)

Guidance literature:

With nitrosonium tetrafluoroborate; copper(ll) bromide; In acetonitrile; at 0 - 20 ℃; Large scale reaction;

DOI:10.1021/op8003184

Reference yield: 95.0%

1,2-dibromo-5-chloro-3-fluorobenzene (208186-78-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-bromo-4-chloro-6-fluorobenzaldehyde (1135531-73-5)

Guidance literature:

1,2-dibromo-5-chloro-3-fluorobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; n-heptane; at -45 - -40 ℃; for 0.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; n-heptane; at -45 - -20 ℃; for 0.25h;

With hydrogenchloride; In diethyl ether; at 0 ℃;

Reference yield: 95.0%

1,2-dibromo-5-chloro-3-fluorobenzene (208186-78-1) → 2-bromo-4-chloro-6-fluorobenzaldehyde (1135531-73-5)

Guidance literature:

With isopropylmagnesium chloride; In tetrahydrofuran; n-heptane; at -40 ℃; for 0.5h; Inert atmosphere;

upstream raw materials:

2-bromo-4-chloro-6-fluorobenzenamine

Downstream raw materials:

2-bromo-4-chloro-6-fluorobenzaldehyde

1-(2-bromo-4-chloro-6-fluorophenyl)-N-hydroxymethanimine

3-(2-bromo-4-chloro-6-fluorophenyl)-5-methyl-[1,2,4]oxadiazole

2-bromo-4-chloro-6-fluoro-N-hydroxybenzamidine

Refernces