3',5'-DICHLORO-2'-HYDROXYACETOPHENONE

Base Information

• Chemical Name: 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE
• CAS No.: 3321-92-4
• Molecular Formula: C8H6Cl2O2
• Molecular Weight: 205.04
• Hs Code.: 29147000
• Mol file: 3321-92-4.mol

Synonyms:2-Acetyl-4,6-dichlorophenol;2'-Hydroxy-3',5'-dichloroacetophenone;1-(3,5-Dichloro-2-hydroxyphenyl)ethanone;Acetophenone,3',5'-dichloro-2'-hydroxy- (6CI,7CI,8CI);3,5-Dichloro-2-hydroxyacetophenone;3',5'-Dichloro-2'-hydroxyacetophenone;4,6-Dichloro-2-acetylphenol;

Chemical Property of 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE

Chemical Property:

• Melting Point: 94-97 °C
• Refractive Index: 1.5490 (estimate)
• Boiling Point: 295.6 °C at 760 mmHg
• PKA: 8.26±0.23(Predicted)
• Flash Point: 132.6 °C
• PSA: 37.30000
• Density: 1.43 g/cm³
• LogP: 2.90160
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Acetone

Purity/Quality:

98% ^*data from raw suppliers

3'',5''-Dichloro-2’-hydroxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE

There total 10 articles about 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetyl chloride (75-36-5) + 2,4-dichlorophenol (120-83-2,40477-79-0) → 1-(3,5-dichloro-2-hydroxyphenyl)-ethanone (3321-92-4)

Guidance literature:

With aluminium trichloride; at 180 ℃; for 0.5h;

DOI:10.1080/00397919608003863

Reference yield: 96.0%

1,3-dichloro-4-acetoxybenzene (6341-97-5) → 1-(3,5-dichloro-2-hydroxyphenyl)-ethanone (3321-92-4)

Guidance literature:

With aluminum (III) chloride; In neat (no solvent); at 140 ℃; for 3h; Inert atmosphere;

DOI:10.1002/adsc.201900749

Reference yield: 80.0%

1-(3,5-dichloro-2-hydroxy-phenyl)-ethanone oxime (55779-51-6) → 1-(3,5-dichloro-2-hydroxyphenyl)-ethanone (3321-92-4)

Guidance literature:

With sodium perborate; In acetic acid; for 5.5h; Heating;

DOI:10.1080/00397910008087181

upstream raw materials:

1,3-dichloro-4-acetoxybenzene

acetyl chloride

2,4-dichlorophenol

1-(3,5-dichloro-2-hydroxy-phenyl)-ethanone oxime

Downstream raw materials:

3',5'-dichloro-2'-hydroxy-3,4-dimethoxy-trans-chalcone

(E)-1-(3,5-Dichloro-2-hydroxy-phenyl)-3-(3-trifluoromethyl-phenyl)-propenone

2,4-dichloro-6-(1-methyl-propenyl)-phenol

2-sec-butyl-4,6-dichloro-phenol

Refernces

• 1、 Takate, Sushama J.,Salve, Supriya P.,Dare, Sushama B.,Karale, Bhausaheb K.,Akolkar, Hemantkumar N.,Falke, Dnyaneshwar B.,Ghungurde, Rahul B.,Mhaske, Sadhana D.. "Synthesis and Antibacterial Screening of Some New Pyrazolylchromones and Pyrazolylcoumaran-3-ones". . p. 525 - 530. Retrieved 2021/02/02.
• 2、 Dofe, Vidya S.,Sarkate, Aniket P.,Shaikh, Zarina M.,Gill, Charansingh H.. "Ultrasound-assisted synthesis and antimicrobial activity of tetrazole-based pyrazole and pyrimidine derivatives". . p. 59 - 65. Retrieved 2018/01/18.