2-PYRIDINESULFONYLACETONITRILE

Base Information

• Chemical Name: 2-PYRIDINESULFONYLACETONITRILE
• CAS No.: 170449-34-0
• Molecular Formula: C₇H₆N₂O₂S
• Molecular Weight: 182.203
• Hs Code.: 2933399090
• Mol file: 170449-34-0.mol

Synonyms:Acetonitrile, (2-pyridinylsulfonyl)- (9CI);(2-Pyridinesulfonyl)acetonitrile;(Pyridin-2-ylsulfonyl)acetonitrile;

Chemical Property of 2-PYRIDINESULFONYLACETONITRILE

Chemical Property:

• Vapor Pressure: 5.72E-08mmHg at 25°C
• Melting Point: 77-79 °C
• Refractive Index: 1.546
• Boiling Point: 440.8 °C at 760 mmHg
• PKA: -3.29±0.19(Predicted)
• Flash Point: 220.4 °C
• PSA: 79.20000
• Density: 1.356 g/cm³
• LogP: 1.45968
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(Pyridin-2-ylsulphonyl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Hazard Codes: Xn:Harmful
• Statements: 20/21/22
• Safety Statements: 22-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (Pyridin-2-ylsulphonyl)acetonitrile is a useful reactant for the preparation of quaternary nitriles by sulfone-?metal exchange and alkylation of pyridylsulfonyl nitriles.

Technology Process of 2-PYRIDINESULFONYLACETONITRILE

There total 2 articles about 2-PYRIDINESULFONYLACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-(pyridin-2-ylthio)acetonitrile (7521-19-9) → 2-(pyridin-2-ylsulfonyl)acetonitrile (170449-34-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 22 ℃; for 48.5833h;

DOI:10.1002/ejoc.201201454

Reference yield:

2-Sulfanylpyridine (2637-34-5,73018-10-7) → 2-(pyridin-2-ylsulfonyl)acetonitrile (170449-34-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran / 0.25 h / 22 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48.58 h / 0 - 22 °C

With 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.201201454

Reference yield: 30.0%

2-(pyridin-2-ylsulfonyl)acetonitrile (170449-34-0) + (Z)-methyl-N-cyanoformimidate (51688-22-3) → (E)-1-[2-cyano-2-(pyridin-2-ylsulfonyl)vinyl]urea (1439992-93-4)

Guidance literature:

2-(pyridin-2-ylsulfonyl)acetonitrile; (Z)-methyl-N-cyanoformimidate; With sodium methylate; In methanol; at 22 ℃; for 4h;

With hydrogenchloride; water; In methanol; at 22 ℃; for 2h;

DOI:10.1002/ejoc.201201454

upstream raw materials:

2-Sulfanylpyridine

2-(pyridin-2-ylthio)acetonitrile

Downstream raw materials:

(E)-1-[2-cyano-2-(pyridin-2-ylsulfonyl)vinyl]urea

Refernces