2-FLUORO-3-NITROBENZOIC ACID

Base Information

• Chemical Name: 2-FLUORO-3-NITROBENZOIC ACID
• CAS No.: 317-46-4
• Molecular Formula: C7H4FNO4
• Molecular Weight: 185.111
• Hs Code.: 29163990
• Mol file: 317-46-4.mol

Synonyms:2-Fluoro-3-nitrobenzoicacid;benzoic acid, 2-fluoro-3-nitro-;

Chemical Property of 2-FLUORO-3-NITROBENZOIC ACID

Chemical Property:

• Vapor Pressure: 2.01E-05mmHg at 25°C
• Refractive Index: 1.588
• Boiling Point: 347.6 °C at 760 mmHg
• PKA: 2.32±0.20(Predicted)
• Flash Point: 164 °C
• PSA: 83.12000
• Density: 1.568 g/cm³
• LogP: 1.95530
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive
• Solubility.: DMSO (Sparingly), Methanol (Slightly)
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-3-nitrobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-3-nitrobenzoic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Technology Process of 2-FLUORO-3-NITROBENZOIC ACID

There total 8 articles about 2-FLUORO-3-NITROBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.87%

carbon dioxide (124-38-9,18923-20-1) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 2-fluoro-3-nitro-benzoic acid (317-46-4)

Guidance literature:

ortho-nitrofluorobenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -80 ℃; for 8h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; for 2h; Solvent; Temperature; Reagent/catalyst;

Reference yield: 82.0%

2-fluoro-3-nitrobenzonitrile (1214328-20-7) → 2-fluoro-3-nitro-benzoic acid (317-46-4)

Guidance literature:

With sulfuric acid; at 120 ℃; for 12h;

Reference yield: 75.0%

2-fluoro-3-nitrotoluene (437-86-5) → 2-fluoro-3-nitro-benzoic acid (317-46-4)

Guidance literature:

With chromium(VI) oxide; potassium hydroxide; In water; at 100 ℃; for 12h; Temperature; Reagent/catalyst;

upstream raw materials:

o-fluoro-benzoic acid

2-Fluorotoluene

2-fluoro-3-nitrotoluene

2-fluoro-3-nitrobenzaldehyde

Downstream raw materials:

(3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone

(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone

N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide

2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide

Refernces

• 1、 -. "Preparation method of 2-fluoro-3-nitrobenzoic acid". Paragraph 0023-0035. . Retrieved 2022/01/08.
• 2、 -. "BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS". Page/Page column 87-88. . Retrieved 2011/06/16.