Pyrimidine, 4-bromo- (8CI,9CI)

Base Information

• Chemical Name: Pyrimidine, 4-bromo- (8CI,9CI)
• CAS No.: 31462-56-3
• Molecular Formula: C4H3BrN2
• Molecular Weight: 158.985
• Hs Code.: 2933599090
• Mol file: 31462-56-3.mol

Synonyms:Pyrimidine, 4-bromo- (8CI,9CI);

Chemical Property of Pyrimidine, 4-bromo- (8CI,9CI)

Chemical Property:

• Vapor Pressure: 0.437mmHg at 25°C
• Refractive Index: 1.568
• Boiling Point: 201.431 °C at 760 mmHg
• PKA: -0.09±0.10(Predicted)
• Flash Point: 75.623 °C
• PSA: 25.78000
• Density: 1.727 g/cm³
• LogP: 1.23910

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromopyrimidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 4-bromo- (8CI,9CI)

There total 2 articles about Pyrimidine, 4-bromo- (8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

pyrimidine-4(3H)-one (51953-18-5,542-27-8) → 4-brornopyrirnidine (31462-56-3)

Guidance literature:

pyrimidine-4(3H)-one; With phosphorus(V) oxybromide; at 80 - 115 ℃; for 4h;

With sodium hydrogencarbonate; In water; at 20 ℃;

Reference yield:

Pyrimidin-4-ol (51953-17-4) → 4-brornopyrirnidine (31462-56-3)

Guidance literature:

With phosphorus(V) oxybromide; at 100 ℃; for 4h;

Reference yield: 98.0%

trimethyltin(IV)chloride (1066-45-1) + 4-brornopyrirnidine (31462-56-3) → 4-(trimethylstannyl)pyrimidine

Guidance literature:

4-brornopyrirnidine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

trimethyltin(IV)chloride; In tetrahydrofuran;

upstream raw materials:

pyrimidine-4(3H)-one

Pyrimidin-4-ol

Downstream raw materials:

4-[(1-methyl-4-phenyl-1H-imidazol-5-yl)ethynyl]pyrimidine

4-(2,5-dimethoxybenzyl)pyrimidine

4-(2-fluorobenzyl)pyrimidine

4-(2-methoxybenzyl)pyrimidine

Refernces

• 1、 -. "THERAPEUTIC AGENTS". Page 60. . Retrieved 2010/02/07.