1-Benzhydryl-3-bromoazetidine

Base Information

• Chemical Name: 1-Benzhydryl-3-bromoazetidine
• CAS No.: 36476-84-3
• Molecular Formula: C16H16BrN
• Molecular Weight: 302.214
• Hs Code.: 2933990090
• Mol file: 36476-84-3.mol

Synonyms:1-Benzhydryl-3-bromo-azetidine;

Chemical Property of 1-Benzhydryl-3-bromoazetidine

Chemical Property:

• Boiling Point: 356.897 °C at 760 mmHg
• Flash Point: 169.646 °C
• PSA: 3.24000
• Density: 1.383 g/cm³
• LogP: 3.79300

Purity/Quality:

99% ^*data from raw suppliers

1-Benzhydryl-3-bromoazetidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzhydryl-3-bromoazetidine

There total 3 articles about 1-Benzhydryl-3-bromoazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(diphenylmethyl)-3-hydroxyazetidine (18621-17-5) → 3-bromo-1-benzhydrylazetidine (36476-84-3)

Guidance literature:

With pyridine; phosphorus tribromide; In 1,2-dichloro-ethane; at 0 - 10 ℃; for 7h; Solvent; Reagent/catalyst; Concentration;

Reference yield: 81.0%

1-benzhydryl-3-azetidinyl methanesulfonate (33301-41-6) → 3-bromo-1-benzhydrylazetidine (36476-84-3)

Guidance literature:

With lithium carbonate; lithium bromide; In tetrahydrofuran;

Reference yield:

→ 3-bromo-1-benzhydrylazetidine (36476-84-3)

Guidance literature:

Verb.5, NaBr;

DOI:10.1021/jo00797a046

upstream raw materials:

1-benzhydryl-3-azetidinyl methanesulfonate

1-(diphenylmethyl)-3-hydroxyazetidine

Downstream raw materials:

diethyl 2-[1-(diphenylmethyl)azetidin-3-yl]propane-1,3-dioate

1-Benzhydryl-4-hydroxymethyl-pyrrolidin-2-one

1-Benzhydryl-4-hydroxymethyl-2-oxo-pyrrolidine-3-carboxylic acid

Refernces

• 1、 Carruthers, Nicholas I.,Wong, Shing-Chun,Chan, Tze-Ming. "A Straightforward Synthesis of Azetidin-3-ylacetic Acid". . p. 430 - 431. Retrieved 2007/10/03.