TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE

Base Information

• Chemical Name: TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE
• CAS No.: 344329-76-6
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.159
• Hs Code.: 29339900
• Mol file: 344329-76-6.mol

Synonyms:3,4,5,6-Tetrahydro-2H-pyran-4-carboxamide;

Chemical Property of TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 181-183°C
• Refractive Index: 1.477
• Boiling Point: 312.074 °C at 760 mmHg
• PKA: 16.31±0.20(Predicted)
• Flash Point: 191.196 °C
• PSA: 52.32000
• Density: 1.114 g/cm³
• LogP: 0.59860
• Storage Temp.: Keep Cold

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Carbamoyltetrahydropyran ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-20/21/22
• Safety Statements: 24/25-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE

There total 5 articles about TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tetrahydro-2H-pyran-4-carboxylic acid (5337-03-1) → tetrahydro-pyran-4-carboxylic acid amide (344329-76-6)

Guidance literature:

tetrahydro-2H-pyran-4-carboxylic acid; With triethylamine; isobutyl chloroformate; In chloroform; at 0 ℃; for 2h; Inert atmosphere;

With ammonia; In chloroform; for 0.25h; Inert atmosphere;

Reference yield: 89.0%

tetrahydropyran-4-carboxylic acid methyl ester (110238-91-0) → tetrahydro-pyran-4-carboxylic acid amide (344329-76-6)

Guidance literature:

With ammonia; In water; at 20 ℃; for 18h;

Reference yield: 62.0%

tetrahydro-2H-pyran-4-carbonylchloride (40191-32-0) → tetrahydro-pyran-4-carboxylic acid amide (344329-76-6)

Guidance literature:

With ammonia; In water; at 0 ℃; for 6h;

upstream raw materials:

tetrahydro-2H-pyran-4-carbonylchloride

tetrahydropyran-4-carboxylic acid methyl ester

tetrahydro-2H-pyran-4-carboxylic acid

tetrahydro-2H-pyran-4-carbonitrile

Downstream raw materials:

4-aminotetrahydropyran

C₁₄H₁₅NO₂

N-{2-chloro-3-[5-(4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Refernces

• 1、 -. "4-Aminotetrahydropyrans process for one-pot synthesis". Paragraph 0014; 0015. . Retrieved 2017/02/02.
• 2、 -. "BIPHENYL COMPOUNDS AND USES THEREOF". Paragraph 00325. . Retrieved 2015/05/19.