2-CHLORO-4-PHENYLPYRIMIDINE

Base Information

• Chemical Name: 2-CHLORO-4-PHENYLPYRIMIDINE
• CAS No.: 13036-50-5
• Molecular Formula: C10H7ClN2
• Molecular Weight: 190.632
• Hs Code.: 2933599090
• Mol file: 13036-50-5.mol

Synonyms:2-Chloro-4-phenylpyrimidine;2-Chloro-6-phenylpyrimidine;

Chemical Property of 2-CHLORO-4-PHENYLPYRIMIDINE

Chemical Property:

• Vapor Pressure: 2.73E-05mmHg at 25°C
• Melting Point: 86 °C
• Refractive Index: 1.593
• Boiling Point: 368.3 °C at 760 mmHg
• PKA: -1.38±0.20(Predicted)
• Flash Point: 208.1 °C
• PSA: 25.78000
• Density: 1.245g/cm³
• LogP: 2.79700
• Storage Temp.: Keep Cold

Purity/Quality:

99%, ^*data from raw suppliers

2-Chloro-4-phenylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

Useful:

Technology Process of 2-CHLORO-4-PHENYLPYRIMIDINE

There total 26 articles about 2-CHLORO-4-PHENYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,6-Dichloropyrimidine (3934-20-1) + phenylboronic acid (98-80-6) → 2-chloro-4-phenylpyrimidine (13036-50-5)

Guidance literature:

With tetrabutylammomium bromide; sodium carbonate; In ethanol; water; at 70 ℃; for 10h; Catalytic behavior;

DOI:10.1016/j.jorganchem.2018.02.030

Reference yield: 84.0%

bromobenzene (108-86-1,52753-63-6) + sodium 2-chloropyrimidine-4-sulfinate → 2-chloro-4-phenylpyrimidine (13036-50-5)

Guidance literature:

With di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02944

Reference yield: 80.0%

2,6-Dichloropyrimidine (3934-20-1) + phenylboronic acid (98-80-6) → 2-chloro-4-phenylpyrimidine (13036-50-5) + 2,4-diphenylpyrimidine (25095-48-1)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; benzene; for 4h; Heating;

DOI:10.3987/COM-00-8890

upstream raw materials:

4-phenyl-1H-pyrimidin-2-one

2,4-dichloro-6-phenyl-pyrimidine

2,6-Dichloropyrimidine

tributylphenylstannane

Downstream raw materials:

4-phenylpyrimidine

2-(methylsulfanyl)-4-phenylpyrimidine

2-(4-(4-phenylpyrimidin-2-ylamino)phenyl)acetic acid

4-(4-phenylpyrimidin-2-ylamino)benzamide

Refernces

• 1、 Feng, Guang-Shou,Guo, Xuan,Meng, Fan-Jie,Shao, Bing-Ru,Shi, Lei,Velopolcek, Maria K.. "Redox deracemization of phosphonate-substituted dihydropyrimidines". supporting information. p. 10570 - 10574. Retrieved 2021/12/27.
• 2、 Wei, Ziyan,Yu, Shouyun,Zhang, Ai Hua,Zhang, Hao. "Access to Cyanoimines Enabled by Dual Photoredox/Copper-Catalyzed Cyanation of O-Acyl Oximes". . p. 7315 - 7320. Retrieved 2020/10/02.