4-Ethoxy-2-Fluoropyridine

Base Information

• Chemical Name: 4-Ethoxy-2-Fluoropyridine
• CAS No.: 175965-82-9
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.145
• Hs Code.: 2933399990
• Mol file: 175965-82-9.mol

Synonyms:Pyridine, 4-ethoxy-2-fluoro- (9CI);

Chemical Property of 4-Ethoxy-2-Fluoropyridine

Chemical Property:

• Vapor Pressure: 0.88mmHg at 25°C
• Refractive Index: 1.471
• Boiling Point: 187.1 °C at 760 mmHg
• PKA: 0.87±0.10(Predicted)
• Flash Point: 67 °C
• PSA: 22.12000
• Density: 1.108g/cm³
• LogP: 1.61940
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-ethoxy-2-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Ethoxy-2-Fluoropyridine

There total 4 articles about 4-Ethoxy-2-Fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dichloro-4-ethoxy-2-fluoropyridine (175965-86-3) → 4-ethoxy-2-fluoropyridine (175965-82-9)

Guidance literature:

With sodium acetate; palladium; In ethanol;

Reference yield:

2,4-difluoropyridine (34941-90-7) + sodium ethanolate (141-52-6) → 4-ethoxy-2-fluoropyridine (175965-82-9)

Guidance literature:

In ethanol; at 0 ℃; for 18h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.03.124

Reference yield:

2,4-difluoropyridine (34941-90-7) + sodium ethanolate (141-52-6) → 4-ethoxy-2-fluoropyridine (175965-82-9) + 2-hydroxy-4-fluoropyridine (96530-75-5)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.03.124

upstream raw materials:

3,5-dichloro-4-ethoxy-2-fluoropyridine

2,4-difluoropyridine

sodium ethanolate

Refernces

• 1、 -. "N-pyridinyl[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide herbicides". . . Retrieved 2008/06/13.