2-Amino-5-methylpyridin-3-ol

Base Information

• Chemical Name: 2-Amino-5-methylpyridin-3-ol
• CAS No.: 20348-17-8
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14052
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90552083
• Wikidata: Q82432078
• Mol file: 20348-17-8.mol

Synonyms:2-amino-5-methylpyridin-3-ol;20348-17-8;2-Amino-3-hydroxy-5-picoline;3-Pyridinol, 2-amino-5-methyl-;SCHEMBL91444;3-Pyridinol,2-amino-5-methyl-;DTXSID90552083;AKOS006328983;SB53898;AS-77500;A4427;CS-0145980

Chemical Property of 2-Amino-5-methylpyridin-3-ol

Chemical Property:

• Vapor Pressure: 5.31E-06mmHg at 25°C
• Refractive Index: 1.626
• Boiling Point: 370.1 °C at 760 mmHg
• PKA: 5.26±0.15(Predicted)
• Flash Point: 177.6 °C
• PSA: 59.14000
• Density: 1.245 g/cm³
• LogP: 1.25900
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5-methylpyridin-3-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(N=C1)N)O

Technology Process of 2-Amino-5-methylpyridin-3-ol

There total 4 articles about 2-Amino-5-methylpyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-5-methylpyridin-2-amine (17282-00-7) → 5-methyl-2-amino-3-pyridinol (20348-17-8)

Guidance literature:

With potassium hydroxide; copper; In monoethylene glycol diethyl ether; at 150 ℃; for 4h;

Reference yield:

5-methyl-2-nitropyridin-3-ol (15128-88-8) → 5-methyl-2-amino-3-pyridinol (20348-17-8)

Guidance literature:

With hydrazine hydrate; nickel; for 2h; Ambient temperature;

DOI:10.1021/jm00394a018

Reference yield:

5-methyl-3-pyridinol (42732-49-0) → 5-methyl-2-amino-3-pyridinol (20348-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: concd. sulfuric acid, concd. nitric acid / Ambient temperature

2: hydrazine hydrate / Raney nickel / 2 h / Ambient temperature

With sulfuric acid; nitric acid; hydrazine hydrate; nickel;

DOI:10.1021/jm00394a018

upstream raw materials:

5-methyl-2-nitropyridin-3-ol

3-bromo-5-methylpyridin-2-amine

5-methyl-3-pyridinol

Refernces

• 1、 Kaminski, James J.,Hilbert, James M.,Pramanik, B. N.,Solomon, Daniel M.,Conn, David J.,et al.. "Antiulcer Agents. 2. Gastric Antisecretory, Cytoprotective, and Metabolic Properties of Substituted Imidazolpyridines and Analogues". . p. 2031 - 2046. Retrieved 2007/10/02.