5-FLUOROINDOLE-3-ACETONITRILE

Base Information

• Chemical Name: 5-FLUOROINDOLE-3-ACETONITRILE
• CAS No.: 73139-85-2
• Molecular Formula: C10H7FN2
• Molecular Weight: 174.177
• Mol file: 73139-85-2.mol

Synonyms:(5-fluoro-1H-indol-3-yl)acetonitrile;1H-indole-3-acetonitrile, 5-fluoro-;

Chemical Property of 5-FLUOROINDOLE-3-ACETONITRILE

Chemical Property:

• Vapor Pressure: 6.83E-06mmHg at 25°C
• Refractive Index: 1.645
• Boiling Point: 377.3 °C at 760 mmHg
• Flash Point: 182 °C
• Density: 1.316 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoroindole-3-acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUOROINDOLE-3-ACETONITRILE

There total 8 articles about 5-FLUOROINDOLE-3-ACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N,N-diethyl-3-aminomethyl-5-fluoro-1H-indole (190182-61-7) + methyl iodide (74-88-4) → 2-(5-fluoro-1H-indol-3-yl)acetonitrile (73139-85-2)

Guidance literature:

In tetrahydrofuran; water; MeI adding to a pre-cooled indole (5 deg C) in THF; stirring overnight; aq. KCN adding; stirring at reflux under Ar;

DOI:10.1111/j.2042-7158.1997.tb06789.x

Reference yield: 88.9%

potassium cyanide + 5-fluoro-1H-indole-3-carbaldehyde (2338-71-8) → 2-(5-fluoro-1H-indol-3-yl)acetonitrile (73139-85-2)

Guidance literature:

5-fluoro-1H-indole-3-carbaldehyde; With sodium tetrahydroborate; In methanol; formamide; for 0.5h;

potassium cyanide; In methanol; formamide; at 100 ℃; for 1h;

Reference yield: 61.0%

5-fluoro-1H-indole (399-52-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + trimethylsilyl cyanide (7677-24-9) → 2-(5-fluoro-1H-indol-3-yl)acetonitrile (73139-85-2)

Guidance literature:

5-fluoro-1H-indole; formaldehyd; With acetic acid; dimethyl amine; In water; at 20 ℃; for 6h;

With 3-(Dimethylaminomethyl)indole; methyl iodide; In dichloromethane; toluene; at 20 ℃; for 12h;

trimethylsilyl cyanide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

upstream raw materials:

N,N-diethyl-3-aminomethyl-5-fluoro-1H-indole

methyl iodide

5-fluoro-1H-indole

3-dimethylaminomethyl-5-fluoroindole

Downstream raw materials:

methyl 2-(5-fluoro-1H-indol-3-yl)acetate

(5-fluoroindol-3-yl)acetic acid

N-[(S)-2-(3-cyanomethyl-5-fluoroindol-1-yl)-1-methylethyl]-2,4-dimethyl-6-nitrobenzenesulfonamide

Refernces

• 1、 -. "Use of derivatives of indoles for the treatment of cancer". Page/Page column 52; 53. . Retrieved 2016/01/09.
• 2、 Go, Mei-Lin,Leow, Jo Lene,Gorla, Suresh Kumar,Schüller, Andreas Peter,Wang, Mei,Casey, Patrick J.. "Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase". experimental part. p. 6838 - 6850. Retrieved 2010/11/18.