5-Chloro-2-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 5-Chloro-2-(trifluoromethyl)pyridine
• CAS No.: 349-94-0
• Molecular Formula: C6H3ClF3N
• Molecular Weight: 181.545
• Hs Code.: 2933399090
• Mol file: 349-94-0.mol

Synonyms:2-Picoline,5-chloro-a,a,a-trifluoro- (8CI);

Chemical Property of 5-Chloro-2-(trifluoromethyl)pyridine

Chemical Property:

• Melting Point: 35-37°C
• Boiling Point: 146 °C at 760 mmHg
• PKA: -1.73±0.22(Predicted)
• Flash Point: 42.1 °C
• PSA: 12.89000
• Density: 1.416 g/cm³
• LogP: 2.75380
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

5-Chloro-2-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T,F
• Statements: 11-25-36/37/38
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-2-(trifluoromethyl)pyridine

There total 7 articles about 5-Chloro-2-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(trifluoromethyl)trimethylsilane (81290-20-2) + 5-chloro-2-iodo-pyridine (244221-57-6) → 5-chloro-2-(trifluoromethyl)pyridine (349-94-0)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; potassium fluoride; copper(l) iodide;

DOI:10.1016/j.tet.2004.09.106

Reference yield: 62.0%

ethyl 5-chloro-2-(trifluoromethyl)nicotinate → 5-chloro-2-(trifluoromethyl)pyridine (349-94-0)

Guidance literature:

With lithium chloride; In 1-methyl-pyrrolidin-2-one; at 200 ℃;

DOI:10.1021/acs.orglett.1c01725

Reference yield:

2,3-dichloro-6-(trifluoromethyl)pyridine (89719-90-4) → 5-chloro-2-(trifluoromethyl)pyridine (349-94-0)

Guidance literature:

With copper; propionic acid; at 135 ℃; for 22h; Reagent/catalyst; Temperature;

upstream raw materials:

α-picoline

(trifluoromethyl)trimethylsilane

5-chloro-2-iodo-pyridine

2-Bromo-5-chloro-pyridine

Downstream raw materials:

3-ethyl-6-trifluoromethyl pyridine

2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile

Refernces

• 1、 -. "METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES". . . Retrieved 2013/10/08.
• 2、 Cottet, Fabrice,Schlosser, Manfred. "Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids". . p. 11869 - 11874. Retrieved 2007/10/03.