1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester

Base Information

• Chemical Name: 1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester
• CAS No.: 578021-55-3
• Molecular Formula: C₁₄H₂₅NO₄
• Molecular Weight: 271.357
• Hs Code.: 2933399090
• Mol file: 578021-55-3.mol

Synonyms:Methyl N-Boc-4-ethylpiperidine-4-carboxylate;

Chemical Property of 1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.549
• Boiling Point: 329.872 °C at 760 mmHg
• PKA: -2.26±0.40(Predicted)
• Flash Point: 153.302 °C
• PSA: 55.84000
• Density: 1.05 g/cm³
• LogP: 2.52460
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyln-boc-4-ethylpiperidine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester

There total 2 articles about 1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.58%

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate (124443-68-1) + ethyl iodide (75-03-6) → 1-tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate (578021-55-3)

Guidance literature:

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

ethyl iodide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

Reference yield:

ethyl bromide (74-96-4) + 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate (124443-68-1) → 1-tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate (578021-55-3)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0960-894X(03)00350-0 DOI:10.1016/j.bmcl.2004.05.014

Reference yield: 98.5%

1-tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate (578021-55-3) → 1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid (188792-67-8)

Guidance literature:

With water; potassium hydroxide; In methanol; at 70 ℃; for 19h;

upstream raw materials:

ethyl bromide

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

ethyl iodide

Downstream raw materials:

1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid

tert-butyl 4-amino-4-ethylpiperidine-1-carboxylate

1-boc-4-ethyl-4-formylpiperidine

Refernces

• 1、 Jiang, Xiao-Hua,Song, Yan-Li,Long, Ya-Qiu. "Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists". . p. 3675 - 3678. Retrieved 2007/10/03.