2-CHLORO-5-FLUORO-3-IODOPYRIDINE

Base Information

• Chemical Name: 2-CHLORO-5-FLUORO-3-IODOPYRIDINE
• CAS No.: 884494-33-1
• Molecular Formula: C₅H₂ClFIN
• Molecular Weight: 257.433
• Mol file: 884494-33-1.mol

Synonyms:2-Chloro-5-fluoro-3-iodopyridine;

Chemical Property of 2-CHLORO-5-FLUORO-3-IODOPYRIDINE

Chemical Property:

• Vapor Pressure: 0.057mmHg at 25°C
• Refractive Index: 1.614
• Boiling Point: 240.941 °C at 760 mmHg
• Flash Point: 99.518 °C
• PSA: 12.89000
• Density: 2.129 g/cm³
• LogP: 2.47870
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99.5% ^*data from raw suppliers

2-Chloro-5-fluoro-3-iodo-pyridine Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-5-FLUORO-3-IODOPYRIDINE

There total 3 articles about 2-CHLORO-5-FLUORO-3-IODOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-chloro-5-fluoronicotinic acid (38186-88-8) → 2-chloro-5-fluoro-3-iodo-pyridine (884494-33-1)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); iodine; palladium diacetate; Inert atmosphere;

DOI:10.1002/jlcr.1887

Reference yield:

(2E,4Z)-ethyl 2-cyano-5-(dimethylamino)-4-fluoro-penta-2,4-dienoate (1316084-72-6) → 2-chloro-5-fluoro-3-iodo-pyridine (884494-33-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 3 h / 45 °C

2: hydrogenchloride; water; trifluoroacetic acid / Inert atmosphere

3: 2,2'-azobis(isobutyronitrile); iodine; palladium diacetate / Inert atmosphere

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); water; iodine; palladium diacetate; trifluoroacetic acid;

DOI:10.1002/jlcr.1887

Reference yield:

ethyl 2-chloro-5-fluoropyridine-3-carboxylate (139911-30-1) → 2-chloro-5-fluoro-3-iodo-pyridine (884494-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water; trifluoroacetic acid / Inert atmosphere

2: 2,2'-azobis(isobutyronitrile); iodine; palladium diacetate / Inert atmosphere

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); water; iodine; palladium diacetate; trifluoroacetic acid;

DOI:10.1002/jlcr.1887

upstream raw materials:

(2E,4Z)-ethyl 2-cyano-5-(dimethylamino)-4-fluoro-penta-2,4-dienoate

2-chloro-5-fluoronicotinic acid

ethyl 2-chloro-5-fluoropyridine-3-carboxylate

Downstream raw materials:

2-chloro-5-fluoronicotinonitrile

N-(2-chloro-5-fluoro-[3,4']bipyridinyl-3'-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide

Refernces