2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL

Base Information

• Chemical Name: 2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL
• CAS No.: 57671-28-0
• Molecular Formula: C17H28O6
• Molecular Weight: 328.406
• Hs Code.: 2909499000
• Mol file: 57671-28-0.mol

Synonyms:Pentaethyleneglycol monobenzyl ether;

Chemical Property of 2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.497
• Boiling Point: 437.172 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 218.194 °C
• PSA: 66.38000
• Density: 1.094 g/cm³
• LogP: 1.26190
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Soluble in DMSO, DCM, DMF

Purity/Quality:

98% ^*data from raw suppliers

Pentaethylene Glycol Monobenzyl Ether >95.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Benzyl-PEG6-alcohol is a PEG linker with a benzyl protecting group and a primary alcohol. The benzyl protecting group can be removed under acidic conditions. The primary alcohol can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Technology Process of 2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL

There total 8 articles about 2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Pentaethylene glycol (4792-15-8) + benzyl chloride (100-44-7) → 2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol (57671-28-0,1201808-31-2)

Guidance literature:

With sodium hydroxide; In water; Heating;

DOI:10.1016/S0040-4039(01)00619-0

Reference yield: 65.0%

Pentaethylene glycol (4792-15-8) + benzyl bromide (100-39-0) → 2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol (57671-28-0,1201808-31-2)

Guidance literature:

Pentaethylene glycol; With sodium; In tetrahydrofuran; Heating;

benzyl bromide; In tetrahydrofuran; for 5h; Heating;

DOI:10.1002/1521-3773(20000717)39:14<2512::AID-ANIE2512>3.0.CO;2-L

Reference yield:

triethylene glycol monobenzyl ether (55489-58-2,1201808-31-2) → 2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethanol (57671-28-0,1201808-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / NaOH, Bu₄NHSO₄ / H₂O / 85 °C

2: acid / methanol

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In methanol; water;

DOI:10.1080/00397919908086236

upstream raw materials:

Pentaethylene glycol

benzyl bromide

benzyl chloride

oxirane

Downstream raw materials:

1-benzyl-15-methoxy-pentaoxyethylene

nonaethylene glycol

1-(triphenylmethyloxy)-26-(phenylmethyloxy)-3,6,9,12,15,18,21,24-octaoxahexaeicosane

26-(phenylmethyloxy)-3,6,9,12,15,18,21,24-octaoxahexaeicosan-1-ol

Refernces

• 1、 -. "SMALL MOLECULES". Page/Page column 16; 17; 39; 40. . Retrieved 2018/11/10.
• 2、 Maniaci, Chiara,Hughes, Scott J.,Testa, Andrea,Chen, Wenzhang,Lamont, Douglas J.,Rocha, Sonia,Alessi, Dario R.,Romeo, Roberto,Ciulli, Alessio. "Homo-PROTACs: Bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation". . . Retrieved 2017/10/16.