4'-Amino-2'-hydroxyacetophenone

Base Information

• Chemical Name: 4'-Amino-2'-hydroxyacetophenone
• CAS No.: 2476-29-1
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2922509090
• Mol file: 2476-29-1.mol

Synonyms:Acetophenone,4'-amino-2'-hydroxy- (6CI,7CI,8CI); 1-(4-Amino-2-hydroxyphenyl)ethanone;2-Acetyl-5-aminophenol

Chemical Property of 4'-Amino-2'-hydroxyacetophenone

Chemical Property:

• Melting Point: 134-135 ºC
• Boiling Point: 331.7°Cat760mmHg
• PKA: 10.21±0.10(Predicted)
• Flash Point: 154.4°C
• PSA: 63.32000
• Density: 1.242g/cm³
• LogP: 1.75820
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% or more ^*data from raw suppliers

1-(4-Amino-2-hydroxyphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-Amino-2'-hydroxyacetophenone

There total 10 articles about 4'-Amino-2'-hydroxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

→ 4-amino-2-hydroxy-acetophenone (2476-29-1)

Guidance literature:

Reference yield: 73.0%

N-(4-acetyl-3-hydroxyphenyl)acetamide (40547-58-8) → 4-amino-2-hydroxy-acetophenone (2476-29-1)

Guidance literature:

With hydrogenchloride; In water; at 50 ℃; for 3h;

DOI:10.1021/jm301913k

Reference yield:

3-acetamidophenyl acetate (6317-89-1) → 4-amino-2-hydroxy-acetophenone (2476-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃

2: aqueous HCl

With hydrogenchloride; aluminium trichloride;

upstream raw materials:

2',4'-dihydroxy-4-acetophenone

N-(4-acetyl-3-hydroxyphenyl)acetamide

acetic acid-(3-butoxy-anilide)

acetic acid-(3-octyloxy-anilide)

Downstream raw materials:

3-ethyl-6-amino-2-hydroxy-benzoic acid

1-(4-(dimethylamino)-2-hydroxyphenyl)ethanone

(E)-1-(4-amino-2-hydroxyphenyl)-3-(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-one

(E)-1-(4-amino-2-hydroxyphenyl)-3-(4-ethylphenyl)prop-2-en-1-one

Refernces

• 1、 -. "N-sulfamoyl-N'-benzopyranpiperidine compounds and uses thereof". Page/Page column 8. . Retrieved 2008/06/13.
• 2、 -. "Primary intermediate for oxidative coloration of hair". . . Retrieved 2008/06/13.