4-(1-Methyl-1H-tetrazol-5-yl)phenylAmine

Base Information

• Chemical Name: 4-(1-Methyl-1H-tetrazol-5-yl)phenylAmine
• CAS No.: 382637-68-5
• Molecular Formula: C8H9N5
• Molecular Weight: 175.193
• Mol file: 382637-68-5.mol

Synonyms:4-(1-Methyl-1H-tetrazol-5-yl)phenylamine;4-(1-Methyl-1H-tetrazol-5-yl)aniline;

Chemical Property of 4-(1-Methyl-1H-tetrazol-5-yl)phenylAmine

Chemical Property:

• Boiling Point: 392.322 °C at 760 mmHg
• Flash Point: 191.07 °C
• PSA: 69.62000
• Density: 1.4 g/cm³
• LogP: 1.04050

Purity/Quality:

99% ^*data from raw suppliers

4-(1-methyl-1H-1,2,3,4-tetrazol-5-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1-Methyl-1H-tetrazol-5-yl)phenylAmine

There total 6 articles about 4-(1-Methyl-1H-tetrazol-5-yl)phenylAmine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-5-(4-nitrophenyl)-1H-tetrazole (20743-51-5) → 4-(1-methyl-1H-tetrazol-5-yl)aniline (382637-68-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; under 3102.89 Torr;

DOI:10.1021/jm049530m

Reference yield:

4-(1-methyl-1H-tetrazol-5-yl)-aniline; hydrochloride → 4-(1-methyl-1H-tetrazol-5-yl)aniline (382637-68-5)

Guidance literature:

With sodium hydroxide; In water;

DOI:10.1134/S1070428020050127

Reference yield:

N-methyl-4-nitrobenzamide (2585-23-1) → 4-(1-methyl-1H-tetrazol-5-yl)aniline (382637-68-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide; trichlorophosphate / acetonitrile / Reflux

2: tin(II) chloride dihdyrate; hydrogenchloride / 3 h / 50 - 70 °C

3: sodium hydroxide / water

With hydrogenchloride; sodium azide; tin(II) chloride dihdyrate; sodium hydroxide; trichlorophosphate; In water; acetonitrile;

DOI:10.1134/S1070428020050127

upstream raw materials:

1-methyl-5-(4-nitrophenyl)-1H-tetrazole

4-nitro-benzoyl chloride

N-methyl-4-nitrobenzamide

4-nitro-benzoic acid

Downstream raw materials:

[4-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester

Refernces

• 1、 -. "SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS". Page/Page column 122. . Retrieved 2009/04/25.
• 2、 -. "N-ureidoalkyl-piperidines as modulators of chemokine receptor activity". . . Retrieved 2008/06/13.