Technology Process of 17α-p-bromobenzoyloxy-4,6-pregnadiene-3,20-dione
There total 3 articles about 17α-p-bromobenzoyloxy-4,6-pregnadiene-3,20-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-Bromobenzoic acid;
With
toluene-4-sulfonic acid; trifluoroacetic anhydride;
In
chloroform;
at 20 ℃;
for 0.5h;
17α-hydroxypregna-4,6-diene-3,20-dione;
In
chloroform;
at 20 ℃;
for 2h;
DOI:10.1016/j.steroids.2009.04.009
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide / methanol / 2 h / Reflux
2: toluene-4-sulfonic acid; trifluoroacetic anhydride / chloroform / 3 h
With
toluene-4-sulfonic acid; trifluoroacetic anhydride; sodium hydroxide;
In
methanol; chloroform;
2: |Steglich Esterification;
DOI:10.1016/j.ejmech.2014.06.008
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide; chloranil / toluene; acetic acid / 4 h / Reflux
2: sodium hydroxide / methanol / 2 h / Reflux
3: toluene-4-sulfonic acid; trifluoroacetic anhydride / chloroform / 3 h
With
chloranil; toluene-4-sulfonic acid; trifluoroacetic anhydride; sodium hydroxide;
In
methanol; chloroform; acetic acid; toluene;
3: |Steglich Esterification;
DOI:10.1016/j.ejmech.2014.06.008
