(5-Bromo-3-methylpyridin-2-YL)methanol

Base Information

• Chemical Name: (5-Bromo-3-methylpyridin-2-YL)methanol
• CAS No.: 245765-71-3
• Molecular Formula: C7H8 Br N O
• Molecular Weight: 202.051
• DSSTox Substance ID: DTXSID60592855
• Wikidata: Q82487190
• Mol file: 245765-71-3.mol

Synonyms:(5-BROMO-3-METHYLPYRIDIN-2-YL)METHANOL;245765-71-3;5-bromo-2-hydroxymethyl-3-methylpyridine;(5-bromo-3-methyl-2-pyridyl)methanol;MFCD19687347;2-Pyridinemethanol, 5-bromo-3-methyl-;5-Bromo-3-methyl-2-pyridinemethanol;2-Pyridinemethanol,5-bromo-3-methyl-;SCHEMBL1577276;DTXSID60592855;FVMSGXSGQKWTHM-UHFFFAOYSA-N;AMY39690;VJA76571;AKOS024074198;AB87971;BS-22105;SY326995;CS-0195182;E91892;EN300-7177049;A877871;Z1269233464

Chemical Property of (5-Bromo-3-methylpyridin-2-YL)methanol

Chemical Property:

• Boiling Point: 290.4±35.0 °C(Predicted)
• PKA: 13.12±0.10(Predicted)
• PSA: 33.12000
• Density: 1.567±0.06 g/cm3(Predicted)
• LogP: 1.64480
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 200.97893
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

(5-Bromo-3-methylpyridin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CN=C1CO)Br

Technology Process of (5-Bromo-3-methylpyridin-2-YL)methanol

There total 4 articles about (5-Bromo-3-methylpyridin-2-YL)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-3-methylpyridine-2-carboxylic acid methyl ester (213771-32-5) → (5-bromo-3-methylpyridin-2-yl)methanol (245765-71-3)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃; for 2h; Temperature;

Reference yield:

(5-bromo-3-methyl-2-pyridyl)methyl acetate → (5-bromo-3-methylpyridin-2-yl)methanol (245765-71-3)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; for 1h;

Reference yield:

5-bromo-3-methylpyridine-2-carboxylic acid (886365-43-1) → (5-bromo-3-methylpyridin-2-yl)methanol (245765-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / 20 - 90 °C

2: sodium tetrahydroborate / methanol / 2 h / 90 °C

With sodium tetrahydroborate; thionyl chloride; In methanol;

upstream raw materials:

5-bromo-3-methylpyridine-2-carboxylic acid

5-bromo-3-methylpyridine-2-carboxylic acid methyl ester

2,5-dibromo-3-methylpyridine

Downstream raw materials:

(S)-(5-(3-(dibenzylamino)chroman-5-yl)-3-methylpyridin-2-yl)methanol

Refernces

• 1、 -. "IMIDAZOPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER". . . Retrieved 2018/04/12.
• 2、 -. "Quinolonecarboxylic acid derivatives or salts thereof". Page column 27. . Retrieved 2010/01/30.