2-Bromo-5-trifluoromethoxypyridine

Base Information

• Chemical Name: 2-Bromo-5-trifluoromethoxypyridine
• CAS No.: 888327-36-4
• Molecular Formula: C6H3BrF3NO
• Molecular Weight: 241.995
• Hs Code.: 2933399090
• Mol file: 888327-36-4.mol

Synonyms:Pyridine,2-bromo-5-(trifluoromethoxy);2-BROMO-5-TRIFLUOROMETHOXYPYRIDINE;

Chemical Property of 2-Bromo-5-trifluoromethoxypyridine

Chemical Property:

• Boiling Point: 194.1 °C at 760 mmHg
• PKA: -3.55±0.10(Predicted)
• Flash Point: 71.2 °C
• PSA: 22.12000
• Density: 1.737 g/cm³
• LogP: 2.74270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-Bromo-5-(trifluoromethoxy)pyridine ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-trifluoromethoxypyridine

There total 7 articles about 2-Bromo-5-trifluoromethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.13%

2-bromo-5-(bromodifluoromethoxy)pyridine → 2-bromo-5-(trifluoromethoxy)pyridine (888327-36-4)

Guidance literature:

With silver tetrafluoroborate; In dichloromethane; at -70 - 20 ℃; for 4h; Large scale;

Reference yield: 81.0%

2-chloro-5-(trifluoromethoxy)pyridine (1206972-45-3) → 2-bromo-5-(trifluoromethoxy)pyridine (888327-36-4)

Guidance literature:

With trimethylsilyl bromide; In propiononitrile; for 24h; Reflux;

Reference yield: 2.9%

6-bromo-pyridin-3-ol (55717-45-8,55717-40-3) + tetrachloromethane (56-23-5) → 2-bromo-5-(trifluoromethoxy)pyridine (888327-36-4)

Guidance literature:

6-bromo-pyridin-3-ol; tetrachloromethane; With antimony pentafluoride; at 150 ℃; for 8h;

With potassium hydroxide; In water;

upstream raw materials:

6-bromo-pyridin-3-ol

tetrachloromethane

2-chloro-5-(trifluoromethoxy)pyridine

6-bromopyridin-3-ylboronic acid

Refernces

• 1、 -. "Iminothiadiazine Dioxide Compounds as BACE Inhibitors, Compositions and Their Use". Paragraph 0631. . Retrieved 2015/11/16.
• 2、 Manteau, Baptiste,Genix, Pierre,Brelot, Lydia,Vors, Jean-Pierre,Pazenok, Sergiy,Giornal, Florence,Leuenberger, Charlotte,Leroux, Frederic R.. "A general approach to (trifluoromethoxy)pyridines: First X-ray structure determinations and quantum chemistry studies". experimental part. p. 6043 - 6066. Retrieved 2011/02/26.