Zoxamide

Base Information

• Chemical Name: Zoxamide
• CAS No.: 156052-68-5
• Deprecated CAS: 160171-18-6
• Molecular Formula: C14H16 Cl3 N O2
• Molecular Weight: 336.646
• European Community (EC) Number: 605-037-1
• UNII: F1XZW465PC
• DSSTox Substance ID: DTXSID9032581
• Nikkaji Number: J1.761.435E
• Wikidata: Q19312105
• ChEMBL ID: CHEMBL1893025
• Mol file: 156052-68-5.mol

Synonyms:RH 7281;RH-7281;RH7281;zoxamide

Chemical Property of Zoxamide

Chemical Property:

• Vapor Pressure: 4.13E-07mmHg at 25°C
• Melting Point: 159.5-161ºC
• Refractive Index: 1.544
• Boiling Point: 415.4°Cat760mmHg
• PKA: 11.20±0.46(Predicted)
• Flash Point: 205°C
• PSA: 46.17000
• Density: 1.289g/cm³
• LogP: 4.39910
• Storage Temp.: 0-6°C
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 335.024662
• Heavy Atom Count: 20
• Complexity: 365

Purity/Quality:

98%,99%, ^*data from raw suppliers

Zoxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Low toxicity by ingestion, inhalation, and skin contact.
• Hazard Codes: Xi,N
• Statements: 43-50/53
• Safety Statements: 24-37-46-60-61

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Pesticides -> Fungicides
• Canonical SMILES: CCC(C)(C(=O)CCl)NC(=O)C1=CC(=C(C(=C1)Cl)C)Cl
• Uses: Zoxamide is a fungacide for control of mildew and late bight. Zoxamide was developped for foliar use on potatoes, vines, and vegetables. Zoxamide is able to specifically target Oomycete fungi; Zoxamid e exhibits strong preventive activity combined with excellent rainfast and residual properties. Agricultural fungicide. Zoxamide is a fungacide for control of mildew and late bight. Zoxamide was developped for foliar use on potatoes, vines, and vegetables. Zoxamide is able to specifically target Oomycete fungi; Zoxamide exhibits strong preventive activity combined with excellent rainfast and residual properties.

Technology Process of Zoxamide

There total 5 articles about Zoxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-chlorovinyl-2-(3,5-dichloro-4-methylphenyl)-4-ethyl-4-methyl-4,5-dihydrooxazole → zoxamide (156052-68-5,160171-18-6)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; water; at 60 ℃; for 1.5h; Reagent/catalyst;

Reference yield: 91.0%

→ zoxamide (156052-68-5,160171-18-6)

Guidance literature:

Reference yield: 87.0%

2-(3,5-dichloro-4-methylphenyl)-4-ethyl-4-methyl-5-methyleneoxazoline (209809-70-1) + trichloroisocyanuric acid (87-90-1) → zoxamide (156052-68-5,160171-18-6)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate;

upstream raw materials:

3,5-dichloro-4-methylbenzoyl chloride

2-(3,5-dichloro-4-methylphenyl)-4-ethyl-4-methyl-5-methyleneoxazoline

trichloroisocyanuric acid

3,5-dichloro-4-methylbenzoic acid

Downstream raw materials:

(+)-S-zoxamide

(-)-R-zoxamide

Refernces

• 1、 -. "Process for the manufacture of acetonylbenzamides". . . Retrieved 2008/06/13.
• 2、 -. "Metal salt catalyzed process to oxazolines and subsequent formation of chloroketones". . . Retrieved 2008/06/13.