(2,4,6-Trichlorophenyl)hydrazine monohydrochloride

Base Information

• Chemical Name: (2,4,6-Trichlorophenyl)hydrazine monohydrochloride
• CAS No.: 2724-66-5
• Molecular Formula: C6H6Cl4N2
• Molecular Weight: 247.939
• European Community (EC) Number: 220-337-9
• UNII: J9P443LM76
• DSSTox Substance ID: DTXSID50181696
• Mol file: 2724-66-5.mol

Synonyms:2724-66-5;(2,4,6-trichlorophenyl)hydrazine hydrochloride;(2,4,6-Trichlorophenyl)hydrazine monohydrochloride;(2,4,6-trichlorophenyl)hydrazine;hydrochloride;J9P443LM76;EINECS 220-337-9;C6H5Cl3N2.ClH;UNII-J9P443LM76;SCHEMBL2071416;C6-H5-Cl3-N2.Cl-H;DTXSID50181696;ADTJGIMHXSBSPS-UHFFFAOYSA-N;AKOS001475828;(2,4,6-Trichlorophenyl)hydrazine, HCl;FT-0654991;(2,4,6-trichlorophenyl)hydrazinehydrochloride;2,4,6-trichlorophenyl hydrazine hydrochloride;(2,4,6-trichlorophenyl)hydrazinemonohydrochloride;A876993;2,4,6-TRICHLOROPHENYLHYDRAZINE HYDROCHLORIDE;HYDRAZINE, (2,4,6-TRICHLOROPHENYL)-, MONOHYDROCHLORIDE;HYDRAZINE, (2,4,6-TRICHLOROPHENYL)-, HYDROCHLORIDE (1:1)

Chemical Property of (2,4,6-Trichlorophenyl)hydrazine monohydrochloride

Chemical Property:

• Vapor Pressure: 0.00574mmHg at 25°C
• Boiling Point: 273.4°Cat760mmHg
• Flash Point: 119.2°C
• PSA: 38.05000
• Density: 1.603g/cm³
• LogP: 4.50770
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 247.925559
• Heavy Atom Count: 12
• Complexity: 121

Purity/Quality:

99%, ^*data from raw suppliers

(2,4,6-Trichlorophenyl)hydrazinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1Cl)NN)Cl)Cl.Cl

Technology Process of (2,4,6-Trichlorophenyl)hydrazine monohydrochloride

There total 3 articles about (2,4,6-Trichlorophenyl)hydrazine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

3-Amino-3-(2,4,6-trichlor-phenylazo)propensaeuremethylester (104891-98-7) → 1,3,5-trichlorobenzene (108-70-3,63697-19-8) + 2,4,6-trichlorophenylhydrazine hydrochloride (2724-66-5) + 2,2',4,4',6,6'-Hexachlor-azobenzen (23914-43-4,18490-44-3)

Guidance literature:

With hydrogenchloride; In methanol; for 0.5h; Ambient temperature;

Reference yield:

2,4,6-trichloroaniline (634-93-5) → 2,4,6-trichlorophenylhydrazine hydrochloride (2724-66-5)

Guidance literature:

2,4,6-trichloroaniline; With hydrogenchloride; sodium nitrite; In water; at -5 - 20 ℃; Inert atmosphere;

With hydrogenchloride; water; tin(ll) chloride; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b01803

Reference yield:

7-Amino-2,2-dimethyl-5-(2,4,6-trichloro-phenyl)-1-oxa-5,6-diaza-spiro[2.4]hept-6-en-4-one (99367-80-3) → 2,4,6-trichlorophenylhydrazine hydrochloride (2724-66-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Na / 2.) 30 min, reflux

2: 35 percent / gas. HCl / methanol / 0.5 h / Ambient temperature

With hydrogenchloride; sodium; In methanol;

upstream raw materials:

3-Amino-3-(2,4,6-trichlor-phenylazo)propensaeuremethylester

7-Amino-2,2-dimethyl-5-(2,4,6-trichloro-phenyl)-1-oxa-5,6-diaza-spiro[2.4]hept-6-en-4-one

2,4,6-trichloroaniline

Downstream raw materials:

mesoaldehyde 1,3-dioxime-2-(2,4,6-trichlorophenyl)hydrazone

4-{1-[(2,4,6-Trichloro-phenyl)-hydrazono]-ethyl}-benzonitrile

5-Isopropyl-1-(2,4,6-trichloro-phenyl)-1H-pyrazole-4-carbonitrile

1-<5-amino-1-(2,4,6,-trichlorophenyl)pyrazol-4-yl>-2-methylpropan-1-one

Refernces

• 1、 Kirschke, Klaus,Moeller, Angela,Schmitz, Ernst. "New Azoolefines and their Acidic Cleavage to Aryldiimines". . p. 893 - 898. Retrieved 2007/10/02.