5-Chloro-2-hydroxypyrazine

Base Information

• Chemical Name: 5-Chloro-2-hydroxypyrazine
• CAS No.: 89180-45-0
• Molecular Formula: C4H3ClN2O
• Molecular Weight: 130.534
• Hs Code.: 2933990090
• Mol file: 89180-45-0.mol

Synonyms:Pyrazinol,5-chloro- (7CI);

Chemical Property of 5-Chloro-2-hydroxypyrazine

Chemical Property:

• Vapor Pressure: 1.23E-07mmHg at 25°C
• Melting Point: 138-140 °C
• Refractive Index: 1.632
• Boiling Point: 419.6 °C at 760 mmHg
• PKA: 10.02±0.40(Predicted)
• Flash Point: 207.5 °C
• PSA: 46.01000
• Density: 1.553g/cm³
• LogP: 0.83560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2-hydroxypyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-2-hydroxypyrazine

There total 3 articles about 5-Chloro-2-hydroxypyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-amino-5-chloropyrazine (33332-29-5) → 5-chloro-1,2-dihydro-2-oxopyrazine (89180-45-0)

Guidance literature:

With sulfuric acid; sodium nitrite; at 0 - 40 ℃;

DOI:10.1016/j.bmc.2019.01.007

Reference yield:

2-Aminopyrazine (5049-61-6) → 5-chloropyrazine-2-ol (89180-45-0)

Guidance literature:

Reference yield:

→ 5-chloropyrazine-2-ol (89180-45-0)

Guidance literature:

2-Amino-5-chlor-pyrazin (III), NaNO2, konz. H2SO4, dann H2O;

upstream raw materials:

2-Aminopyrazine

2-amino-5-chloropyrazine

Downstream raw materials:

2,5-dichloropyrazine

Refernces

• 1、 -. "AMIDOPYRAZOLE DERIVATIVE". Page/Page column 28-29. . Retrieved 2010/11/23.