6-Fluoropyridine-2-boronic acid

Base Information

• Chemical Name: 6-Fluoropyridine-2-boronic acid
• CAS No.: 916176-61-9
• Molecular Formula: C5H5BFNO2
• Molecular Weight: 140.91
• Hs Code.: 2933399990
• Mol file: 916176-61-9.mol

Synonyms:(6-Fluoropyridin-2-yl)boronicacid;

Chemical Property of 6-Fluoropyridine-2-boronic acid

Chemical Property:

• Boiling Point: 326.8 °C at 760 mmHg
• PKA: 6.76±0.53(Predicted)
• Flash Point: 151.5 °C
• PSA: 53.35000
• Density: 1.34 g/cm³
• LogP: -1.09950
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99.0% ^*data from raw suppliers

6-Fluoropyridine-2-boronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Fluoropyridine-2-boronic acid

There total 1 articles about 6-Fluoropyridine-2-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-bromo-6-fluoropyridine (144100-07-2) → (6-fluoropyridin-2-yl)boronic acid (916176-61-9)

Guidance literature:

2-bromo-6-fluoropyridine; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; toluene; at -78 - 0 ℃; for 3.75h;

With hydrogenchloride; water; In tetrahydrofuran; hexane; toluene; at 20 ℃; for 1h;

Reference yield: 92.0%

(6-fluoropyridin-2-yl)boronic acid (916176-61-9) + 5-bromo-4-cyclopentyl-1H-pyrrole-2-carboxylic acid (4-methylcyclohexyl)ester → 4-methylcyclohexyl 4-cyclopentyl-5-(6-fluoropyridin-2-yl)-1H-pyrrole-2-carboxylate

Guidance literature:

With sodium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 1h; Microwave irradiation; Inert atmosphere;

Reference yield: 86.0%

(6-fluoropyridin-2-yl)boronic acid (916176-61-9) + 2-chloro-5-{3-methyl-4-[(2-methyladamantan-2-yl)oxy]phenyl}pyridine → 2-(6-fluoropyridin-2-yl)-5-(3-methyl-4-((2-methyladamantan-2-yl)oxy)phenyl)pyridine

Guidance literature:

(6-fluoropyridin-2-yl)boronic acid; 2-chloro-5-{3-methyl-4-[(2-methyladamantan-2-yl)oxy]phenyl}pyridine; With sodium carbonate; In water; for 0.183333h; Inert atmosphere;

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; at 120 ℃; for 0.833333h; Inert atmosphere; Microwave irradiation;

upstream raw materials:

2-bromo-6-fluoropyridine

Refernces